Bovine maternal, Fetal and neonatal responses to bovine viral diarrhea virus infections

Clayton L Kelling, Christina L. Topliff

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Due to the affinity of BVDV for the fetus and for cells of lymphatic organs of infected cattle, reproductive failure or immunosuppression, respectively, are likely consequences of BVDV infections of susceptible cattle. Infection of susceptible pregnant cattle with noncytopathic (ncp) BVDV results in transplacental infection with induction of maternal and fetal innate and adaptive immune responses. Differences in maternal innate and adaptive immune responses are evident in late gestation between cows carrying fetuses persistently-infected (PI) with BVDV and cows with fetuses transiently-infected with BVDV. Fetal innate and adaptive immune responses to ncp BVDV infection are defined by fetal age and developmental stage of the fetal immune system. Since a functional fetal adaptive immune response does not occur in the early fetus, immunotolerance to ncp BVDV is established, virus replicates unrestricted in fetal tissues and calves are born immunotolerant and PI with the virus. In the last trimester of gestation, the fetal immune system is adequately developed to respond in an efficacious manner, most commonly resulting in the birth of a clinically normal calf with pre-colostral antibodies. Immunosuppression due to postnatal acute ncp BVDV infections of susceptible calves may contribute to the occurrence and severity of multi-factorial respiratory tract and enteric diseases.

Original languageEnglish (US)
Pages (from-to)20-25
Number of pages6
JournalBiologicals
Volume41
Issue number1
DOIs
StatePublished - Jan 1 2013

Fingerprint

Bovine Viral Diarrhea Viruses
Immune system
Virus Diseases
Viruses
Adaptive Immunity
Fetus
Mothers
Innate Immunity
Infection
Antibodies
Immunosuppression
Tissue
Immune System
Respiratory Tract Diseases
Pregnancy
Third Pregnancy Trimester
Gestational Age
Parturition

Keywords

  • Bovine viral diarrhea virus
  • Fetal responses
  • Maternal responses
  • Neonatal responses

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology
  • Immunology and Microbiology(all)
  • Pharmacology

Cite this

Bovine maternal, Fetal and neonatal responses to bovine viral diarrhea virus infections. / Kelling, Clayton L; Topliff, Christina L.

In: Biologicals, Vol. 41, No. 1, 01.01.2013, p. 20-25.

Research output: Contribution to journalArticle

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