Bone mineral density-affecting genes in Africans

Gordon Gong, Gleb Haynatzki, Vera Haynatzka, Ryan Howell, Sade Kosoko-Lasaki, Yun Xin Fu, Fei Yu, John C. Gallagher, M. Roy Wilson

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: We have recently reported the role of environmental exposure in the ethnic diversity of bone mineral density (BMD). Potential genetic difference has not been adequately assessed. Purpose: To determine allele frequencies of EMD-affecting genes and their association with BMD in Africans. Methods: Allele frequencies at 18 polymorphic sites in 13 genes that affect BMD Asians and/or Caucasians were determined in 143 recent immigrants (55 men and 88 women, 18-51 years of age) from sob-Saharan Sudan to the United States. Genetic association studies were performed. Results. Among the 14 single-nucleotide polymorphisms (SNPs), 10 were significantry different in adele frequency between Sudanese and Asians, and 10 between Sudanese and Caucasians. Only the osteocalcin gene was not significantly different in allele frequency among Sudanese, Asians and Caucasians. Allele frequencies in the TGFβ, COLIA1 and CSR genes were extremely low (<0.04) in the Sudanese. Frequencies of microsatellite alleles in four genes were significantly afferent arnong Sudanese, Asians and Caucasians. SNPs in the VDR and ERα genes were associated with BMD and/or BMC (bone mineral content) at several bone sites. Conclusions: Genetic difference may play a role in the ethnic diversity in BMD and/or BMC.

Original languageEnglish (US)
Pages (from-to)1102-1108
Number of pages7
JournalJournal of the National Medical Association
Volume98
Issue number7
StatePublished - Jul 1 2006

Fingerprint

Bone Density
Gene Frequency
Genes
Bone and Bones
Single Nucleotide Polymorphism
Sudan
Osteocalcin
Environmental Exposure
Genetic Association Studies
Microsatellite Repeats

Keywords

  • Africans
  • Bone
  • Genetics
  • Polymorphism
  • Sudanese

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gong, G., Haynatzki, G., Haynatzka, V., Howell, R., Kosoko-Lasaki, S., Fu, Y. X., ... Wilson, M. R. (2006). Bone mineral density-affecting genes in Africans. Journal of the National Medical Association, 98(7), 1102-1108.

Bone mineral density-affecting genes in Africans. / Gong, Gordon; Haynatzki, Gleb; Haynatzka, Vera; Howell, Ryan; Kosoko-Lasaki, Sade; Fu, Yun Xin; Yu, Fei; Gallagher, John C.; Wilson, M. Roy.

In: Journal of the National Medical Association, Vol. 98, No. 7, 01.07.2006, p. 1102-1108.

Research output: Contribution to journalArticle

Gong, G, Haynatzki, G, Haynatzka, V, Howell, R, Kosoko-Lasaki, S, Fu, YX, Yu, F, Gallagher, JC & Wilson, MR 2006, 'Bone mineral density-affecting genes in Africans', Journal of the National Medical Association, vol. 98, no. 7, pp. 1102-1108.
Gong G, Haynatzki G, Haynatzka V, Howell R, Kosoko-Lasaki S, Fu YX et al. Bone mineral density-affecting genes in Africans. Journal of the National Medical Association. 2006 Jul 1;98(7):1102-1108.
Gong, Gordon ; Haynatzki, Gleb ; Haynatzka, Vera ; Howell, Ryan ; Kosoko-Lasaki, Sade ; Fu, Yun Xin ; Yu, Fei ; Gallagher, John C. ; Wilson, M. Roy. / Bone mineral density-affecting genes in Africans. In: Journal of the National Medical Association. 2006 ; Vol. 98, No. 7. pp. 1102-1108.
@article{e58ee05c499b4227a85ce3e39f3995ee,
title = "Bone mineral density-affecting genes in Africans",
abstract = "Background: We have recently reported the role of environmental exposure in the ethnic diversity of bone mineral density (BMD). Potential genetic difference has not been adequately assessed. Purpose: To determine allele frequencies of EMD-affecting genes and their association with BMD in Africans. Methods: Allele frequencies at 18 polymorphic sites in 13 genes that affect BMD Asians and/or Caucasians were determined in 143 recent immigrants (55 men and 88 women, 18-51 years of age) from sob-Saharan Sudan to the United States. Genetic association studies were performed. Results. Among the 14 single-nucleotide polymorphisms (SNPs), 10 were significantry different in adele frequency between Sudanese and Asians, and 10 between Sudanese and Caucasians. Only the osteocalcin gene was not significantly different in allele frequency among Sudanese, Asians and Caucasians. Allele frequencies in the TGFβ, COLIA1 and CSR genes were extremely low (<0.04) in the Sudanese. Frequencies of microsatellite alleles in four genes were significantly afferent arnong Sudanese, Asians and Caucasians. SNPs in the VDR and ERα genes were associated with BMD and/or BMC (bone mineral content) at several bone sites. Conclusions: Genetic difference may play a role in the ethnic diversity in BMD and/or BMC.",
keywords = "Africans, Bone, Genetics, Polymorphism, Sudanese",
author = "Gordon Gong and Gleb Haynatzki and Vera Haynatzka and Ryan Howell and Sade Kosoko-Lasaki and Fu, {Yun Xin} and Fei Yu and Gallagher, {John C.} and Wilson, {M. Roy}",
year = "2006",
month = "7",
day = "1",
language = "English (US)",
volume = "98",
pages = "1102--1108",
journal = "Journal of the National Medical Association",
issn = "1943-4693",
publisher = "National Medical Association",
number = "7",

}

TY - JOUR

T1 - Bone mineral density-affecting genes in Africans

AU - Gong, Gordon

AU - Haynatzki, Gleb

AU - Haynatzka, Vera

AU - Howell, Ryan

AU - Kosoko-Lasaki, Sade

AU - Fu, Yun Xin

AU - Yu, Fei

AU - Gallagher, John C.

AU - Wilson, M. Roy

PY - 2006/7/1

Y1 - 2006/7/1

N2 - Background: We have recently reported the role of environmental exposure in the ethnic diversity of bone mineral density (BMD). Potential genetic difference has not been adequately assessed. Purpose: To determine allele frequencies of EMD-affecting genes and their association with BMD in Africans. Methods: Allele frequencies at 18 polymorphic sites in 13 genes that affect BMD Asians and/or Caucasians were determined in 143 recent immigrants (55 men and 88 women, 18-51 years of age) from sob-Saharan Sudan to the United States. Genetic association studies were performed. Results. Among the 14 single-nucleotide polymorphisms (SNPs), 10 were significantry different in adele frequency between Sudanese and Asians, and 10 between Sudanese and Caucasians. Only the osteocalcin gene was not significantly different in allele frequency among Sudanese, Asians and Caucasians. Allele frequencies in the TGFβ, COLIA1 and CSR genes were extremely low (<0.04) in the Sudanese. Frequencies of microsatellite alleles in four genes were significantly afferent arnong Sudanese, Asians and Caucasians. SNPs in the VDR and ERα genes were associated with BMD and/or BMC (bone mineral content) at several bone sites. Conclusions: Genetic difference may play a role in the ethnic diversity in BMD and/or BMC.

AB - Background: We have recently reported the role of environmental exposure in the ethnic diversity of bone mineral density (BMD). Potential genetic difference has not been adequately assessed. Purpose: To determine allele frequencies of EMD-affecting genes and their association with BMD in Africans. Methods: Allele frequencies at 18 polymorphic sites in 13 genes that affect BMD Asians and/or Caucasians were determined in 143 recent immigrants (55 men and 88 women, 18-51 years of age) from sob-Saharan Sudan to the United States. Genetic association studies were performed. Results. Among the 14 single-nucleotide polymorphisms (SNPs), 10 were significantry different in adele frequency between Sudanese and Asians, and 10 between Sudanese and Caucasians. Only the osteocalcin gene was not significantly different in allele frequency among Sudanese, Asians and Caucasians. Allele frequencies in the TGFβ, COLIA1 and CSR genes were extremely low (<0.04) in the Sudanese. Frequencies of microsatellite alleles in four genes were significantly afferent arnong Sudanese, Asians and Caucasians. SNPs in the VDR and ERα genes were associated with BMD and/or BMC (bone mineral content) at several bone sites. Conclusions: Genetic difference may play a role in the ethnic diversity in BMD and/or BMC.

KW - Africans

KW - Bone

KW - Genetics

KW - Polymorphism

KW - Sudanese

UR - http://www.scopus.com/inward/record.url?scp=33746859770&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33746859770&partnerID=8YFLogxK

M3 - Article

C2 - 16895279

AN - SCOPUS:33746859770

VL - 98

SP - 1102

EP - 1108

JO - Journal of the National Medical Association

JF - Journal of the National Medical Association

SN - 1943-4693

IS - 7

ER -