Bone marrow transplantation with high‐dose cytosine arabinoside

R. H. Herzig, H. M. Lazarus, J. Graham‐Pole, S. Gross, P. Coccia, E. M. Gordon, S. Strandjord, G. L. Phillips, G. P. Herzig

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Eleven patients received allogeneic bone marrow from all HCA‐identical sibling for the treatment of acute leukemia. The preparative regiment included high‐dose cytosine arabinoside (Ara‐C), 3 g/m2q 12 h for 12 doses, and 1000 rad single‐fraction total body irradiation (5 patients) or 1200 rad fractionated total body irradiation (6 patients). The 5 patients receiving the 1000 rad single‐fraction regimen were transplanted in relapse, while the 6 patients receiving the 1200 rad fractionated program were transplanted during remission. Both regimens were well‐tolerated, but the single‐dose radiation regimen was associated with more severe skin problems. Bone marrow engraftment was documented in 10 of 10 evaluable patients, occurring 2‐3 weeks after marrow infusion. No recurrences have been observed during the brief follow‐up time.

Original languageEnglish (US)
Pages (from-to)235-238
Number of pages4
JournalMedical and Pediatric Oncology
Volume10
Issue number1 S
DOIs
StatePublished - 1982

Fingerprint

Cytarabine
Bone Marrow Transplantation
Whole-Body Irradiation
Bone Marrow
Recurrence
Siblings
Leukemia
Radiation
Skin

Keywords

  • acute leukemia
  • bone marrow transplantation
  • cytosine arabinoside

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Cancer Research

Cite this

Herzig, R. H., Lazarus, H. M., Graham‐Pole, J., Gross, S., Coccia, P., Gordon, E. M., ... Herzig, G. P. (1982). Bone marrow transplantation with high‐dose cytosine arabinoside. Medical and Pediatric Oncology, 10(1 S), 235-238. https://doi.org/10.1002/mpo.2950100724

Bone marrow transplantation with high‐dose cytosine arabinoside. / Herzig, R. H.; Lazarus, H. M.; Graham‐Pole, J.; Gross, S.; Coccia, P.; Gordon, E. M.; Strandjord, S.; Phillips, G. L.; Herzig, G. P.

In: Medical and Pediatric Oncology, Vol. 10, No. 1 S, 1982, p. 235-238.

Research output: Contribution to journalArticle

Herzig, RH, Lazarus, HM, Graham‐Pole, J, Gross, S, Coccia, P, Gordon, EM, Strandjord, S, Phillips, GL & Herzig, GP 1982, 'Bone marrow transplantation with high‐dose cytosine arabinoside', Medical and Pediatric Oncology, vol. 10, no. 1 S, pp. 235-238. https://doi.org/10.1002/mpo.2950100724
Herzig RH, Lazarus HM, Graham‐Pole J, Gross S, Coccia P, Gordon EM et al. Bone marrow transplantation with high‐dose cytosine arabinoside. Medical and Pediatric Oncology. 1982;10(1 S):235-238. https://doi.org/10.1002/mpo.2950100724
Herzig, R. H. ; Lazarus, H. M. ; Graham‐Pole, J. ; Gross, S. ; Coccia, P. ; Gordon, E. M. ; Strandjord, S. ; Phillips, G. L. ; Herzig, G. P. / Bone marrow transplantation with high‐dose cytosine arabinoside. In: Medical and Pediatric Oncology. 1982 ; Vol. 10, No. 1 S. pp. 235-238.
@article{d79d491cf12c44dea1f3530616bfb08f,
title = "Bone marrow transplantation with high‐dose cytosine arabinoside",
abstract = "Eleven patients received allogeneic bone marrow from all HCA‐identical sibling for the treatment of acute leukemia. The preparative regiment included high‐dose cytosine arabinoside (Ara‐C), 3 g/m2q 12 h for 12 doses, and 1000 rad single‐fraction total body irradiation (5 patients) or 1200 rad fractionated total body irradiation (6 patients). The 5 patients receiving the 1000 rad single‐fraction regimen were transplanted in relapse, while the 6 patients receiving the 1200 rad fractionated program were transplanted during remission. Both regimens were well‐tolerated, but the single‐dose radiation regimen was associated with more severe skin problems. Bone marrow engraftment was documented in 10 of 10 evaluable patients, occurring 2‐3 weeks after marrow infusion. No recurrences have been observed during the brief follow‐up time.",
keywords = "acute leukemia, bone marrow transplantation, cytosine arabinoside",
author = "Herzig, {R. H.} and Lazarus, {H. M.} and J. Graham‐Pole and S. Gross and P. Coccia and Gordon, {E. M.} and S. Strandjord and Phillips, {G. L.} and Herzig, {G. P.}",
year = "1982",
doi = "10.1002/mpo.2950100724",
language = "English (US)",
volume = "10",
pages = "235--238",
journal = "Pediatric Blood and Cancer",
issn = "1545-5009",
publisher = "Wiley-Liss Inc.",
number = "1 S",

}

TY - JOUR

T1 - Bone marrow transplantation with high‐dose cytosine arabinoside

AU - Herzig, R. H.

AU - Lazarus, H. M.

AU - Graham‐Pole, J.

AU - Gross, S.

AU - Coccia, P.

AU - Gordon, E. M.

AU - Strandjord, S.

AU - Phillips, G. L.

AU - Herzig, G. P.

PY - 1982

Y1 - 1982

N2 - Eleven patients received allogeneic bone marrow from all HCA‐identical sibling for the treatment of acute leukemia. The preparative regiment included high‐dose cytosine arabinoside (Ara‐C), 3 g/m2q 12 h for 12 doses, and 1000 rad single‐fraction total body irradiation (5 patients) or 1200 rad fractionated total body irradiation (6 patients). The 5 patients receiving the 1000 rad single‐fraction regimen were transplanted in relapse, while the 6 patients receiving the 1200 rad fractionated program were transplanted during remission. Both regimens were well‐tolerated, but the single‐dose radiation regimen was associated with more severe skin problems. Bone marrow engraftment was documented in 10 of 10 evaluable patients, occurring 2‐3 weeks after marrow infusion. No recurrences have been observed during the brief follow‐up time.

AB - Eleven patients received allogeneic bone marrow from all HCA‐identical sibling for the treatment of acute leukemia. The preparative regiment included high‐dose cytosine arabinoside (Ara‐C), 3 g/m2q 12 h for 12 doses, and 1000 rad single‐fraction total body irradiation (5 patients) or 1200 rad fractionated total body irradiation (6 patients). The 5 patients receiving the 1000 rad single‐fraction regimen were transplanted in relapse, while the 6 patients receiving the 1200 rad fractionated program were transplanted during remission. Both regimens were well‐tolerated, but the single‐dose radiation regimen was associated with more severe skin problems. Bone marrow engraftment was documented in 10 of 10 evaluable patients, occurring 2‐3 weeks after marrow infusion. No recurrences have been observed during the brief follow‐up time.

KW - acute leukemia

KW - bone marrow transplantation

KW - cytosine arabinoside

UR - http://www.scopus.com/inward/record.url?scp=0020424868&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020424868&partnerID=8YFLogxK

U2 - 10.1002/mpo.2950100724

DO - 10.1002/mpo.2950100724

M3 - Article

C2 - 6761567

AN - SCOPUS:0020424868

VL - 10

SP - 235

EP - 238

JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

SN - 1545-5009

IS - 1 S

ER -