Bone marrow necrosis obscuring the diagnosis of acute promyelocytic leukemia

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Bone marrow necrosis is a rare and ominous complication of hematologic malignancy which is often associated with bone pain in the lower back and extremities. Widespread marrow necrosis makes a definitive diagnosis through bone marrow biopsy difficult. An accurate diagnosis is imperative in patients with promyelocytic leukemia (FAB-M3) because disseminated intravascular coagulation and hemorrhage secondary to release of tissue thromboplastins from the malignant cell population requires prompt and anticipatory therapy. The following case report describes a patient wkth acute leukemia and massive bone marrow necrosis which obscured the correct diagnosis of promyelocytic leukemia.

Original languageEnglish (US)
Pages (from-to)51-54
Number of pages4
JournalHematologic Pathology
Volume2
Issue number1
StatePublished - Jan 1 1988

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Acute Promyelocytic Leukemia
Osteonecrosis
Bone Marrow
Leukemia
Disseminated Intravascular Coagulation
Thromboplastin
Hematologic Neoplasms
Lower Extremity
Necrosis
Hemorrhage
Biopsy
Bone and Bones
Pain
Population
Therapeutics

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Hematology

Cite this

Bone marrow necrosis obscuring the diagnosis of acute promyelocytic leukemia. / Wisecarver, James Lowell; Harrington, D.

In: Hematologic Pathology, Vol. 2, No. 1, 01.01.1988, p. 51-54.

Research output: Contribution to journalArticle

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