Bone marrow necrosis obscuring the diagnosis of acute promyelocytic leukemia

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Abstract

Bone marrow necrosis is a rare and ominous complication of hematologic malignancy which is often associated with bone pain in the lower back and extremities. Widespread marrow necrosis makes a definitive diagnosis through bone marrow biopsy difficult. An accurate diagnosis is imperative in patients with promyelocytic leukemia (FAB-M3) because disseminated intravascular coagulation and hemorrhage secondary to release of tissue thromboplastins from the malignant cell population requires prompt and anticipatory therapy. The following case report describes a patient wkth acute leukemia and massive bone marrow necrosis which obscured the correct diagnosis of promyelocytic leukemia.

Original languageEnglish (US)
Pages (from-to)51-54
Number of pages4
JournalHematologic Pathology
Volume2
Issue number1
Publication statusPublished - Jan 1 1988

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ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Hematology

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