Bone marrow involvement in Burkitt's lymphoma

Richard D. Brunning, Robert W. McKenna, Clara D. Bloomfield, Peter Coccia, Kazimiera J. Gajl‐Peczalska

Research output: Contribution to journalArticle

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Abstract

Thirteen patients with a malignant lymphoma exhibiting the cytologic characteristics of Burkitt's lymphoma manifested marrow involvement at the time of initial diagnosis (11 patients) or later in the course of the disease (two patients). Eleven patients were 16 years of age or younger. Eight had evidence of abdominal disease, five in the ileocecal area. Despite extensive marrow involvement in most of these patients, frankly leukemic blood pictures were uncommon. Platelet counts and absolute neutrophil counts were frequently normal. Membrane surface markers were studied in four patients. The malignant cells from three exhibited μ λ surface immunoglobulin; the cells from the other manifested μ k surface immunoglobulin. All of the patients had a rapid clinical course in spite of intensive chemotherapy. The median survival from detection of marrow involvement was 2.5 months.

Original languageEnglish (US)
Pages (from-to)1771-1779
Number of pages9
JournalCancer
Volume40
Issue number4
DOIs
StatePublished - Oct 1977

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Burkitt Lymphoma
Bone Marrow
B-Cell Antigen Receptors
Platelet Count
Lymphoma
Neutrophils
Drug Therapy
Membranes
Survival

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Brunning, R. D., McKenna, R. W., Bloomfield, C. D., Coccia, P., & Gajl‐Peczalska, K. J. (1977). Bone marrow involvement in Burkitt's lymphoma. Cancer, 40(4), 1771-1779. https://doi.org/10.1002/1097-0142(197710)40:4<1771::AID-CNCR2820400456>3.0.CO;2-5

Bone marrow involvement in Burkitt's lymphoma. / Brunning, Richard D.; McKenna, Robert W.; Bloomfield, Clara D.; Coccia, Peter; Gajl‐Peczalska, Kazimiera J.

In: Cancer, Vol. 40, No. 4, 10.1977, p. 1771-1779.

Research output: Contribution to journalArticle

Brunning, RD, McKenna, RW, Bloomfield, CD, Coccia, P & Gajl‐Peczalska, KJ 1977, 'Bone marrow involvement in Burkitt's lymphoma', Cancer, vol. 40, no. 4, pp. 1771-1779. https://doi.org/10.1002/1097-0142(197710)40:4<1771::AID-CNCR2820400456>3.0.CO;2-5
Brunning RD, McKenna RW, Bloomfield CD, Coccia P, Gajl‐Peczalska KJ. Bone marrow involvement in Burkitt's lymphoma. Cancer. 1977 Oct;40(4):1771-1779. https://doi.org/10.1002/1097-0142(197710)40:4<1771::AID-CNCR2820400456>3.0.CO;2-5
Brunning, Richard D. ; McKenna, Robert W. ; Bloomfield, Clara D. ; Coccia, Peter ; Gajl‐Peczalska, Kazimiera J. / Bone marrow involvement in Burkitt's lymphoma. In: Cancer. 1977 ; Vol. 40, No. 4. pp. 1771-1779.
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