Bombesin-induced gastroprotection

Sonlee D. West, David W. Mercer

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

Bombesin is an endogenous gut peptide that is prominent in the stomach. In addition to its effects on modulating acid and gut peptide secretion, recent evidence indicates that bombesin is a potent gastroprotective agent. This review article examines the ability of bombesin to prevent gastric injury. Its protective actions appear to be mediated primarily via the release of endogenous gastrin, as gastroprotection is negated by blockade of gastrin receptors. Bombesin-induced gastroprotection and gastrin release are modified by somatostatin. Immunoneutralization of endogenous somatostatin increases the ability of bombesin to prevent gastric injury by increasing gastrin release. In mechanistic studies, ablation of capsaicin-sensitive afferent neurons abolishes bombesin-induced gastroprotection while cyclo-oxygenase inhibition partially reverses this effect. Nitric oxide synthase inhibition also negates bombesin-induced gastroprotection as well as the ability of bombesin to increase gastric mucosal blood flow. Taken together, the available evidence indicates that bombesin causes release of endogenous gastrin that activates sensory neurons located in the gastric mucosa. Activation of sensory neurons causes increased production of nitric oxide through activation of constitutive nitric oxide synthase, which leads to a resultant increase in gastric mucosal blood flow and renders the stomach less susceptible to damage from luminal irritants.

Original languageEnglish (US)
Pages (from-to)227-231
Number of pages5
JournalAnnals of surgery
Volume241
Issue number2
DOIs
StatePublished - Feb 1 2005

Fingerprint

Bombesin
Stomach
Gastrins
Sensory Receptor Cells
Somatostatin
Nitric Oxide Synthase
Cholecystokinin B Receptor
Afferent Neurons
Peptides
Irritants
Capsaicin
Wounds and Injuries
Prostaglandin-Endoperoxide Synthases
Gastric Mucosa
Nitric Oxide
Acids

ASJC Scopus subject areas

  • Surgery

Cite this

Bombesin-induced gastroprotection. / West, Sonlee D.; Mercer, David W.

In: Annals of surgery, Vol. 241, No. 2, 01.02.2005, p. 227-231.

Research output: Contribution to journalReview article

West, Sonlee D. ; Mercer, David W. / Bombesin-induced gastroprotection. In: Annals of surgery. 2005 ; Vol. 241, No. 2. pp. 227-231.
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