Body mass index, chronic atrophic gastritis and heartburn: A population-based study among 8936 older adults from Germany

L. Gao, M. N. Weck, D. Rothenbacher, H. Brenner

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background Obesity and overweight have been positively related to gastro-oesophageal reflux disease (GERD). It has been suggested that this relationship is as a consequence of an increased gastric acid reflux, which is caused by an enhanced intra-abdominal pressure. Aim To assess potential interaction of the association between body mass index (BMI) and GERD by chronic atrophic gastritis, which goes along with decreased acid production. Methods In the baseline examination of ESTHER, a study conducted in 9953 older adults in Saarland, information on frequency of heartburn, potential risk factors and medical history was obtained by self-administered standardized questionnaire. Serological measurements of pepsinogen I and II were taken for definition of chronic atrophic gastritis. Results In total, 2565 (28.7%) of the included subjects experienced heartburn within the previous 4 weeks. A pronounced dose-response relationship was observed between BMI and heartburn occurrence (P < 0.001) among people without chronic atrophic gastritis, but not among people with chronic atrophic gastritis (P-value for interaction = 0.018). Obese/overweight people with chronic atrophic gastritis had a much lower risk of heartburn compared with obese/overweight people without chronic atrophic gastritis (OR = 0.31, 95% CI = 0.24-0.40). Conclusion Our results are consistent with the hypothesis that BMI is related positively to GERD symptoms by its impact on acid reflux.

Original languageEnglish (US)
Pages (from-to)296-302
Number of pages7
JournalAlimentary Pharmacology and Therapeutics
Volume32
Issue number2
DOIs
StatePublished - Jul 15 2010

Fingerprint

Atrophic Gastritis
Heartburn
Germany
Body Mass Index
Esophageal Diseases
Gastroesophageal Reflux
Population
Pepsinogen C
Pepsinogen A
Acids
Obesity
Pressure

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology
  • Pharmacology (medical)

Cite this

Body mass index, chronic atrophic gastritis and heartburn : A population-based study among 8936 older adults from Germany. / Gao, L.; Weck, M. N.; Rothenbacher, D.; Brenner, H.

In: Alimentary Pharmacology and Therapeutics, Vol. 32, No. 2, 15.07.2010, p. 296-302.

Research output: Contribution to journalArticle

@article{1fc5439e02f1456c89008cad07a0dfce,
title = "Body mass index, chronic atrophic gastritis and heartburn: A population-based study among 8936 older adults from Germany",
abstract = "Background Obesity and overweight have been positively related to gastro-oesophageal reflux disease (GERD). It has been suggested that this relationship is as a consequence of an increased gastric acid reflux, which is caused by an enhanced intra-abdominal pressure. Aim To assess potential interaction of the association between body mass index (BMI) and GERD by chronic atrophic gastritis, which goes along with decreased acid production. Methods In the baseline examination of ESTHER, a study conducted in 9953 older adults in Saarland, information on frequency of heartburn, potential risk factors and medical history was obtained by self-administered standardized questionnaire. Serological measurements of pepsinogen I and II were taken for definition of chronic atrophic gastritis. Results In total, 2565 (28.7{\%}) of the included subjects experienced heartburn within the previous 4 weeks. A pronounced dose-response relationship was observed between BMI and heartburn occurrence (P < 0.001) among people without chronic atrophic gastritis, but not among people with chronic atrophic gastritis (P-value for interaction = 0.018). Obese/overweight people with chronic atrophic gastritis had a much lower risk of heartburn compared with obese/overweight people without chronic atrophic gastritis (OR = 0.31, 95{\%} CI = 0.24-0.40). Conclusion Our results are consistent with the hypothesis that BMI is related positively to GERD symptoms by its impact on acid reflux.",
author = "L. Gao and Weck, {M. N.} and D. Rothenbacher and H. Brenner",
year = "2010",
month = "7",
day = "15",
doi = "10.1111/j.1365-2036.2010.04334.x",
language = "English (US)",
volume = "32",
pages = "296--302",
journal = "Alimentary Pharmacology and Therapeutics",
issn = "0269-2813",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Body mass index, chronic atrophic gastritis and heartburn

T2 - A population-based study among 8936 older adults from Germany

AU - Gao, L.

AU - Weck, M. N.

AU - Rothenbacher, D.

AU - Brenner, H.

PY - 2010/7/15

Y1 - 2010/7/15

N2 - Background Obesity and overweight have been positively related to gastro-oesophageal reflux disease (GERD). It has been suggested that this relationship is as a consequence of an increased gastric acid reflux, which is caused by an enhanced intra-abdominal pressure. Aim To assess potential interaction of the association between body mass index (BMI) and GERD by chronic atrophic gastritis, which goes along with decreased acid production. Methods In the baseline examination of ESTHER, a study conducted in 9953 older adults in Saarland, information on frequency of heartburn, potential risk factors and medical history was obtained by self-administered standardized questionnaire. Serological measurements of pepsinogen I and II were taken for definition of chronic atrophic gastritis. Results In total, 2565 (28.7%) of the included subjects experienced heartburn within the previous 4 weeks. A pronounced dose-response relationship was observed between BMI and heartburn occurrence (P < 0.001) among people without chronic atrophic gastritis, but not among people with chronic atrophic gastritis (P-value for interaction = 0.018). Obese/overweight people with chronic atrophic gastritis had a much lower risk of heartburn compared with obese/overweight people without chronic atrophic gastritis (OR = 0.31, 95% CI = 0.24-0.40). Conclusion Our results are consistent with the hypothesis that BMI is related positively to GERD symptoms by its impact on acid reflux.

AB - Background Obesity and overweight have been positively related to gastro-oesophageal reflux disease (GERD). It has been suggested that this relationship is as a consequence of an increased gastric acid reflux, which is caused by an enhanced intra-abdominal pressure. Aim To assess potential interaction of the association between body mass index (BMI) and GERD by chronic atrophic gastritis, which goes along with decreased acid production. Methods In the baseline examination of ESTHER, a study conducted in 9953 older adults in Saarland, information on frequency of heartburn, potential risk factors and medical history was obtained by self-administered standardized questionnaire. Serological measurements of pepsinogen I and II were taken for definition of chronic atrophic gastritis. Results In total, 2565 (28.7%) of the included subjects experienced heartburn within the previous 4 weeks. A pronounced dose-response relationship was observed between BMI and heartburn occurrence (P < 0.001) among people without chronic atrophic gastritis, but not among people with chronic atrophic gastritis (P-value for interaction = 0.018). Obese/overweight people with chronic atrophic gastritis had a much lower risk of heartburn compared with obese/overweight people without chronic atrophic gastritis (OR = 0.31, 95% CI = 0.24-0.40). Conclusion Our results are consistent with the hypothesis that BMI is related positively to GERD symptoms by its impact on acid reflux.

UR - http://www.scopus.com/inward/record.url?scp=77953778252&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953778252&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2036.2010.04334.x

DO - 10.1111/j.1365-2036.2010.04334.x

M3 - Article

C2 - 20456301

AN - SCOPUS:77953778252

VL - 32

SP - 296

EP - 302

JO - Alimentary Pharmacology and Therapeutics

JF - Alimentary Pharmacology and Therapeutics

SN - 0269-2813

IS - 2

ER -