Board-invited review: Porcine mucosal immunity of the gastrointestinal tract

T. E. Burkey, K. A. Skjolaas, J. E. Minton

Research output: Contribution to journalReview article

38 Citations (Scopus)

Abstract

The gastrointestinal tract (GIT) constitutes one of the largest immunological organs of the body. The GIT must permit absorption of nutrients while also maintaining the ability to respond appropriately to a diverse milieu of dietary and microbial antigenic components. Because of the diverse population of antigenic components within the GIT, a sophisticated mucosal immune system has evolved that relies on collaboration between the innate and adaptive arms of immunity. The collaborative, mucosal immune effort offers protection from harmful pathogens while also being tolerant of dietary antigens and normal microbial flora. Knowledge with respect to porcine mucosal immunity is important as we strive to understand the interrelationships among GIT physiology, immunology, and the resident microbiota. The aim of this review is to provide a descriptive overview of GIT immunity and components of the mucosal immune system and to highlight differences that exist between the porcine species and other mammals.

Original languageEnglish (US)
Pages (from-to)1493-1501
Number of pages9
JournalJournal of animal science
Volume87
Issue number4
DOIs
StatePublished - Apr 1 2009

Fingerprint

mucosal immunity
Mucosal Immunity
gastrointestinal system
Gastrointestinal Tract
Swine
swine
immune system
Immune System
immunity
Microbiota
Adaptive Immunity
Allergy and Immunology
immunology
Mammals
physiology
mammals
antigens
microorganisms
Antigens
Food

Keywords

  • Gut-associated lymphoid tissue
  • Intestinal epithelial cell
  • Mucosal immunity
  • Pig

ASJC Scopus subject areas

  • Food Science
  • Animal Science and Zoology
  • Genetics

Cite this

Board-invited review : Porcine mucosal immunity of the gastrointestinal tract. / Burkey, T. E.; Skjolaas, K. A.; Minton, J. E.

In: Journal of animal science, Vol. 87, No. 4, 01.04.2009, p. 1493-1501.

Research output: Contribution to journalReview article

Burkey, T. E. ; Skjolaas, K. A. ; Minton, J. E. / Board-invited review : Porcine mucosal immunity of the gastrointestinal tract. In: Journal of animal science. 2009 ; Vol. 87, No. 4. pp. 1493-1501.
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