Blueberry muffin rash, hyperbilirubinemia, and hypoglycemia: A case of hemolytic disease of the fetus and newborn due to anti-Kpa

J. E. Brumbaugh, S. Morgan, J. C. Beck, N. Zantek, S. Kearney, C. M. Bendel, K. D. Roberts

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Hemolytic disease of the fetus and newborn occurs when maternal IgG antibodies cross the placenta and cause hemolysis of fetal red blood cells. Kp a is a low frequency red blood cell antigen that has rarely been implicated in hemolytic disease of the fetus and newborn. The few reported cases attributed to anti-Kp a have typically had minimal clinical consequences. We report a critically ill neonate who presented with purpura, respiratory failure, severe liver dysfunction, hyperbilirubinemia, hypoglycemia and anemia. This case report broadens the spectrum of neonatal disease associated with anti-Kp a, addresses the evaluation of hemolysis with liver failure in a neonate, and emphasizes the importance of screening for antibodies to low frequency red blood cell antigens in suspected hemolytic disease of the fetus and newborn.

Original languageEnglish (US)
Pages (from-to)373-376
Number of pages4
JournalJournal of Perinatology
Volume31
Issue number5
DOIs
StatePublished - May 1 2011

Fingerprint

Blueberry Plants
Fetal Erythroblastosis
Hyperbilirubinemia
Exanthema
Hypoglycemia
Fetus
Erythrocytes
Hemolysis
Infant, Newborn, Diseases
Antigens
Purpura
Antibodies
Liver Failure
Fetal Blood
Critical Illness
Respiratory Insufficiency
Placenta
Liver Diseases
Anemia
Immunoglobulin G

Keywords

  • Kell
  • Kp
  • blueberry muffin rash
  • extramedullary hematopoiesis
  • hemolytic disease of the fetus and newborn
  • hyperbilirubinemia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Blueberry muffin rash, hyperbilirubinemia, and hypoglycemia : A case of hemolytic disease of the fetus and newborn due to anti-Kpa. / Brumbaugh, J. E.; Morgan, S.; Beck, J. C.; Zantek, N.; Kearney, S.; Bendel, C. M.; Roberts, K. D.

In: Journal of Perinatology, Vol. 31, No. 5, 01.05.2011, p. 373-376.

Research output: Contribution to journalArticle

Brumbaugh, J. E. ; Morgan, S. ; Beck, J. C. ; Zantek, N. ; Kearney, S. ; Bendel, C. M. ; Roberts, K. D. / Blueberry muffin rash, hyperbilirubinemia, and hypoglycemia : A case of hemolytic disease of the fetus and newborn due to anti-Kpa. In: Journal of Perinatology. 2011 ; Vol. 31, No. 5. pp. 373-376.
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