Block ionomer complex micelles with cross-linked cores for drug delivery

Jong Oh Kim, Nataliya V. Nukolova, Hardeep S. Oberoi, Alexander V. Kabanov, Tatiana K Bronich

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Soft polymeric nanomaterials were synthesized by template-assisted method involving condensation of the poly(ethylene oxide)-b-polycarboxylate anions by metal ions into core-shell block ionomer complex micelles followed by chemical cross-linking of the polyion chains in the micelle cores. The resulting materials represent nanogels and are capable of swelling in a pH-dependent manner. The structural determinants that guide the self-assembly of the initial micelle templates and the swelling behavior of the cross-linked micelles include the block ionomer structure, the chemical nature of metal ions, the structure of the cross-links and the degree of cross-linking. The application of these materials for loading and release of a drug, cisplatin, is evaluated. These cross-linked block ionomer micelles have promise for delivery of pharmaceutical agents.

Original languageEnglish (US)
Pages (from-to)708-718
Number of pages11
JournalPolymer Science - Series A
Volume51
Issue number6
DOIs
StatePublished - Jun 1 2009

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Ionomers
Micelles
Drug delivery
Metal ions
Swelling
Polyethylene oxides
Nanostructured materials
Pharmaceutical Preparations
Drug products
Self assembly
Cisplatin
Anions
Condensation
Negative ions

ASJC Scopus subject areas

  • Polymers and Plastics
  • Materials Chemistry

Cite this

Block ionomer complex micelles with cross-linked cores for drug delivery. / Kim, Jong Oh; Nukolova, Nataliya V.; Oberoi, Hardeep S.; Kabanov, Alexander V.; Bronich, Tatiana K.

In: Polymer Science - Series A, Vol. 51, No. 6, 01.06.2009, p. 708-718.

Research output: Contribution to journalArticle

Kim, Jong Oh ; Nukolova, Nataliya V. ; Oberoi, Hardeep S. ; Kabanov, Alexander V. ; Bronich, Tatiana K. / Block ionomer complex micelles with cross-linked cores for drug delivery. In: Polymer Science - Series A. 2009 ; Vol. 51, No. 6. pp. 708-718.
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