Blind comparison of patient preference for flavored colestid granules and questran light

P. W. Jungnickel, M. S. Shaefer, P. A. Maloley, James R Campbell, G. G. Shawaryn, G. B. Goris, T. H. Oliphant, D. R. De Almentero, C. Mailjiot

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

OBJECTIVE: To compare the sensory and mixability characteristics of Flavored Colestid Granules (a new colestipol formulation) with Questran Light (the most recent cholestyramine formulation). METHODOLOGY: Seventy-two nonsmoking adults between the ages of 25 and 64 years were enrolled in the study. Subjects assessed the sensory and mixability characteristics of each product in chilled bottled water and orange juice after at least a one-hour fast. Products were administered in a double-blind, randomized fashion. The sensory characteristics that were rated included overall rating, aftertaste, appearance, aroma, color, consistency, flavor, sweetness, mouthfeel, and thickness. Each characteristic was rated with a nine-point hedonic scale. Mixability of the products was assessed on a five-point scale. Subjects also were asked to choose which product they preferred as to sensory and mixability characteristics in each vehicle. RESULTS: Fifty-three of the 72 subjects preferred the sensory characteristics of Flavored Colestid Granules in water (p<0.001). Questran Light was preferred by 61 subjects when mixed in orange juice (p<0.001). The sensory characteristic rating scores also supported subject preferences for Flavored Colestid Granules in water and Questran Light in orange juice. Mixability of Flavored Colestid Granules was rated significantly better (p<0.001) than Questran Light in water. There was no significant difference for mixability between the products in orange juice. CONCLUSIONS: Questran Light was significantly preferred on a sensory basis when mixed in orange juice. Flavored Colestid Granules was significantly preferred over Questran Light for both sensory and mixability characteristics with water as the vehicle.

Original languageEnglish (US)
Pages (from-to)700-703
Number of pages4
JournalAnnals of Pharmacotherapy
Volume27
Issue number6
DOIs
StatePublished - Jun 1993

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Colestipol
Cholestyramine Resin
Patient Preference
Light
Water
Pleasure
Drinking Water
Color

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Jungnickel, P. W., Shaefer, M. S., Maloley, P. A., Campbell, J. R., Shawaryn, G. G., Goris, G. B., ... Mailjiot, C. (1993). Blind comparison of patient preference for flavored colestid granules and questran light. Annals of Pharmacotherapy, 27(6), 700-703. https://doi.org/10.1177/106002809302700603

Blind comparison of patient preference for flavored colestid granules and questran light. / Jungnickel, P. W.; Shaefer, M. S.; Maloley, P. A.; Campbell, James R; Shawaryn, G. G.; Goris, G. B.; Oliphant, T. H.; De Almentero, D. R.; Mailjiot, C.

In: Annals of Pharmacotherapy, Vol. 27, No. 6, 06.1993, p. 700-703.

Research output: Contribution to journalArticle

Jungnickel, PW, Shaefer, MS, Maloley, PA, Campbell, JR, Shawaryn, GG, Goris, GB, Oliphant, TH, De Almentero, DR & Mailjiot, C 1993, 'Blind comparison of patient preference for flavored colestid granules and questran light', Annals of Pharmacotherapy, vol. 27, no. 6, pp. 700-703. https://doi.org/10.1177/106002809302700603
Jungnickel, P. W. ; Shaefer, M. S. ; Maloley, P. A. ; Campbell, James R ; Shawaryn, G. G. ; Goris, G. B. ; Oliphant, T. H. ; De Almentero, D. R. ; Mailjiot, C. / Blind comparison of patient preference for flavored colestid granules and questran light. In: Annals of Pharmacotherapy. 1993 ; Vol. 27, No. 6. pp. 700-703.
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abstract = "OBJECTIVE: To compare the sensory and mixability characteristics of Flavored Colestid Granules (a new colestipol formulation) with Questran Light (the most recent cholestyramine formulation). METHODOLOGY: Seventy-two nonsmoking adults between the ages of 25 and 64 years were enrolled in the study. Subjects assessed the sensory and mixability characteristics of each product in chilled bottled water and orange juice after at least a one-hour fast. Products were administered in a double-blind, randomized fashion. The sensory characteristics that were rated included overall rating, aftertaste, appearance, aroma, color, consistency, flavor, sweetness, mouthfeel, and thickness. Each characteristic was rated with a nine-point hedonic scale. Mixability of the products was assessed on a five-point scale. Subjects also were asked to choose which product they preferred as to sensory and mixability characteristics in each vehicle. RESULTS: Fifty-three of the 72 subjects preferred the sensory characteristics of Flavored Colestid Granules in water (p<0.001). Questran Light was preferred by 61 subjects when mixed in orange juice (p<0.001). The sensory characteristic rating scores also supported subject preferences for Flavored Colestid Granules in water and Questran Light in orange juice. Mixability of Flavored Colestid Granules was rated significantly better (p<0.001) than Questran Light in water. There was no significant difference for mixability between the products in orange juice. CONCLUSIONS: Questran Light was significantly preferred on a sensory basis when mixed in orange juice. Flavored Colestid Granules was significantly preferred over Questran Light for both sensory and mixability characteristics with water as the vehicle.",
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AU - Goris, G. B.

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AU - De Almentero, D. R.

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N2 - OBJECTIVE: To compare the sensory and mixability characteristics of Flavored Colestid Granules (a new colestipol formulation) with Questran Light (the most recent cholestyramine formulation). METHODOLOGY: Seventy-two nonsmoking adults between the ages of 25 and 64 years were enrolled in the study. Subjects assessed the sensory and mixability characteristics of each product in chilled bottled water and orange juice after at least a one-hour fast. Products were administered in a double-blind, randomized fashion. The sensory characteristics that were rated included overall rating, aftertaste, appearance, aroma, color, consistency, flavor, sweetness, mouthfeel, and thickness. Each characteristic was rated with a nine-point hedonic scale. Mixability of the products was assessed on a five-point scale. Subjects also were asked to choose which product they preferred as to sensory and mixability characteristics in each vehicle. RESULTS: Fifty-three of the 72 subjects preferred the sensory characteristics of Flavored Colestid Granules in water (p<0.001). Questran Light was preferred by 61 subjects when mixed in orange juice (p<0.001). The sensory characteristic rating scores also supported subject preferences for Flavored Colestid Granules in water and Questran Light in orange juice. Mixability of Flavored Colestid Granules was rated significantly better (p<0.001) than Questran Light in water. There was no significant difference for mixability between the products in orange juice. CONCLUSIONS: Questran Light was significantly preferred on a sensory basis when mixed in orange juice. Flavored Colestid Granules was significantly preferred over Questran Light for both sensory and mixability characteristics with water as the vehicle.

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