Blepharoptosis and central nervous system abnormalities in combined valproate and hydantoin embryopathy

James W Gigantelli, Stephen R. Braddock, Lenworth N. Johnson

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Purpose: To report a case of intrauterine anticonvulsant exposure with subsequent ocular adnexal manifestations. Methods: Case report. Results: An 18-month-old child with known anticonvulsant embryopathy was referred for the management of bilateral congenital blepharoptosis. Physical examination confirmed ocular and nonocular external manifestations of valproate and hydantoin embryopathies. Cavum septum pellucidum, mild sulcation defects, and cerebellar atrophy were identified on neuroimaging. Conclusions: To our knowledge, our patient represents the second reported case of anomalous septum pellucidum after intrauterine valproate exposure. Clinicians evaluating patients with craniofacial features associated with intrauterine valproate exposure should recognize that concomitant anomalies of the central nervous system, including the septum pellucidum, might exist.

Original languageEnglish (US)
Pages (from-to)52-54
Number of pages3
JournalOphthalmic Plastic and Reconstructive Surgery
Volume16
Issue number1
DOIs
StatePublished - Jan 1 2000

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Septum Pellucidum
Hydantoins
Blepharoptosis
Nervous System Malformations
Fetal Diseases
Valproic Acid
Central Nervous System
Anticonvulsants
Eye Manifestations
Neuroimaging
Physical Examination
Atrophy

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology

Cite this

Blepharoptosis and central nervous system abnormalities in combined valproate and hydantoin embryopathy. / Gigantelli, James W; Braddock, Stephen R.; Johnson, Lenworth N.

In: Ophthalmic Plastic and Reconstructive Surgery, Vol. 16, No. 1, 01.01.2000, p. 52-54.

Research output: Contribution to journalReview article

Gigantelli, James W ; Braddock, Stephen R. ; Johnson, Lenworth N. / Blepharoptosis and central nervous system abnormalities in combined valproate and hydantoin embryopathy. In: Ophthalmic Plastic and Reconstructive Surgery. 2000 ; Vol. 16, No. 1. pp. 52-54.
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