Bioreducible polycations in nucleic acid delivery

Past, present, and future trends

David Oupicky, Jing Li

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Polycations that are degradable by reduction of disulfide bonds are developed for applications in delivery of nucleic acids. This Feature Article surveys methods of synthesis of bioreducible polycations and discusses current understanding of the mechanism of action of bioreducible polyplexes. Emphasis is placed on the relationship between the biological redox environment and toxicity, trafficking, transfection activity, and in vivo behavior of bioreducible polycations and polyplexes. This Feature Article provides an overview of the current status of research into the chemistry of bioreducible polycations and their use in nucleic acid delivery.

Original languageEnglish (US)
Pages (from-to)908-922
Number of pages15
JournalMacromolecular Bioscience
Volume14
Issue number7
DOIs
StatePublished - Jan 1 2014

Fingerprint

Nucleic acids
Nucleic Acids
Toxicity
Disulfides
Oxidation-Reduction
Transfection
polycations
Research

Keywords

  • bioreducible
  • disulfides
  • gene delivery
  • polycations
  • polyplexes

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Bioreducible polycations in nucleic acid delivery : Past, present, and future trends. / Oupicky, David; Li, Jing.

In: Macromolecular Bioscience, Vol. 14, No. 7, 01.01.2014, p. 908-922.

Research output: Contribution to journalArticle

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