Biomimetic Nanofibers as Artificial Stem Cell Niche

Xiaowei Li, Yu Hao Cheng, Jose Roman, Hai Quan Mao

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Stem cell niche provides a complex array of biochemical and physical signals in a temporally and spatially defined fashion, which engages and instructs stem cells to proliferate, migrate, and differentiate. Understanding molecular and structural components of stem cell niche and their respective functions is critical to the development of effective methodologies for stem cell manipulation. Polymeric nanofiber matrices have been developed to mimic the key physical and structural characteristics of stem cell niche. In this chapter, three major methods for preparation of polymeric nanofibers are reviewed, including electrospinning, solution phase separation, and self-assembly, followed by case studies on various nanofiber matrices to regulate stem cell adhesion, morphology/alignment, migration, proliferation, differentiation, and maturation. In particular, the function of nanofibers for the delivery of stem cells to regenerate various types of tissue is highlighted. Lastly, critical challenges and future directions in the development of biomimetic nanofibers as an artificial stem cell niche for regenerative medicine applications are discussed.

Original languageEnglish (US)
Title of host publicationBiology and Engineering of Stem Cell Niches
PublisherElsevier Inc.
Pages411-427
Number of pages17
ISBN (Electronic)9780128027561
ISBN (Print)9780128027349
DOIs
StatePublished - Apr 14 2017

Fingerprint

Artificial Cells
Stem Cell Niche
Nanofibers
Biomimetics
Stem cells
Stem Cells
Regenerative Medicine
Cell Adhesion
Cell adhesion
Electrospinning
Phase separation
Self assembly
Tissue

Keywords

  • Biomimetic
  • Nanofiber
  • Polymer
  • Stem cell niche
  • Tissue regeneration

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Li, X., Cheng, Y. H., Roman, J., & Mao, H. Q. (2017). Biomimetic Nanofibers as Artificial Stem Cell Niche. In Biology and Engineering of Stem Cell Niches (pp. 411-427). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-802734-9.00026-3

Biomimetic Nanofibers as Artificial Stem Cell Niche. / Li, Xiaowei; Cheng, Yu Hao; Roman, Jose; Mao, Hai Quan.

Biology and Engineering of Stem Cell Niches. Elsevier Inc., 2017. p. 411-427.

Research output: Chapter in Book/Report/Conference proceedingChapter

Li, X, Cheng, YH, Roman, J & Mao, HQ 2017, Biomimetic Nanofibers as Artificial Stem Cell Niche. in Biology and Engineering of Stem Cell Niches. Elsevier Inc., pp. 411-427. https://doi.org/10.1016/B978-0-12-802734-9.00026-3
Li X, Cheng YH, Roman J, Mao HQ. Biomimetic Nanofibers as Artificial Stem Cell Niche. In Biology and Engineering of Stem Cell Niches. Elsevier Inc. 2017. p. 411-427 https://doi.org/10.1016/B978-0-12-802734-9.00026-3
Li, Xiaowei ; Cheng, Yu Hao ; Roman, Jose ; Mao, Hai Quan. / Biomimetic Nanofibers as Artificial Stem Cell Niche. Biology and Engineering of Stem Cell Niches. Elsevier Inc., 2017. pp. 411-427
@inbook{57c0a019f14f45c88b15de5913a2211f,
title = "Biomimetic Nanofibers as Artificial Stem Cell Niche",
abstract = "Stem cell niche provides a complex array of biochemical and physical signals in a temporally and spatially defined fashion, which engages and instructs stem cells to proliferate, migrate, and differentiate. Understanding molecular and structural components of stem cell niche and their respective functions is critical to the development of effective methodologies for stem cell manipulation. Polymeric nanofiber matrices have been developed to mimic the key physical and structural characteristics of stem cell niche. In this chapter, three major methods for preparation of polymeric nanofibers are reviewed, including electrospinning, solution phase separation, and self-assembly, followed by case studies on various nanofiber matrices to regulate stem cell adhesion, morphology/alignment, migration, proliferation, differentiation, and maturation. In particular, the function of nanofibers for the delivery of stem cells to regenerate various types of tissue is highlighted. Lastly, critical challenges and future directions in the development of biomimetic nanofibers as an artificial stem cell niche for regenerative medicine applications are discussed.",
keywords = "Biomimetic, Nanofiber, Polymer, Stem cell niche, Tissue regeneration",
author = "Xiaowei Li and Cheng, {Yu Hao} and Jose Roman and Mao, {Hai Quan}",
year = "2017",
month = "4",
day = "14",
doi = "10.1016/B978-0-12-802734-9.00026-3",
language = "English (US)",
isbn = "9780128027349",
pages = "411--427",
booktitle = "Biology and Engineering of Stem Cell Niches",
publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Biomimetic Nanofibers as Artificial Stem Cell Niche

AU - Li, Xiaowei

AU - Cheng, Yu Hao

AU - Roman, Jose

AU - Mao, Hai Quan

PY - 2017/4/14

Y1 - 2017/4/14

N2 - Stem cell niche provides a complex array of biochemical and physical signals in a temporally and spatially defined fashion, which engages and instructs stem cells to proliferate, migrate, and differentiate. Understanding molecular and structural components of stem cell niche and their respective functions is critical to the development of effective methodologies for stem cell manipulation. Polymeric nanofiber matrices have been developed to mimic the key physical and structural characteristics of stem cell niche. In this chapter, three major methods for preparation of polymeric nanofibers are reviewed, including electrospinning, solution phase separation, and self-assembly, followed by case studies on various nanofiber matrices to regulate stem cell adhesion, morphology/alignment, migration, proliferation, differentiation, and maturation. In particular, the function of nanofibers for the delivery of stem cells to regenerate various types of tissue is highlighted. Lastly, critical challenges and future directions in the development of biomimetic nanofibers as an artificial stem cell niche for regenerative medicine applications are discussed.

AB - Stem cell niche provides a complex array of biochemical and physical signals in a temporally and spatially defined fashion, which engages and instructs stem cells to proliferate, migrate, and differentiate. Understanding molecular and structural components of stem cell niche and their respective functions is critical to the development of effective methodologies for stem cell manipulation. Polymeric nanofiber matrices have been developed to mimic the key physical and structural characteristics of stem cell niche. In this chapter, three major methods for preparation of polymeric nanofibers are reviewed, including electrospinning, solution phase separation, and self-assembly, followed by case studies on various nanofiber matrices to regulate stem cell adhesion, morphology/alignment, migration, proliferation, differentiation, and maturation. In particular, the function of nanofibers for the delivery of stem cells to regenerate various types of tissue is highlighted. Lastly, critical challenges and future directions in the development of biomimetic nanofibers as an artificial stem cell niche for regenerative medicine applications are discussed.

KW - Biomimetic

KW - Nanofiber

KW - Polymer

KW - Stem cell niche

KW - Tissue regeneration

UR - http://www.scopus.com/inward/record.url?scp=85040637493&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85040637493&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-802734-9.00026-3

DO - 10.1016/B978-0-12-802734-9.00026-3

M3 - Chapter

AN - SCOPUS:85040637493

SN - 9780128027349

SP - 411

EP - 427

BT - Biology and Engineering of Stem Cell Niches

PB - Elsevier Inc.

ER -