Biomedical production of implants by additive electro-chemical and physical processes

Paulo Bartolo, Jean Pierre Kruth, Jorge Silva, Gideon Levy, Ajay Malshe, Kamlakar Rajurkar, Mamoru Mitsuishi, Joaquim Ciurana, Ming Leu

Research output: Contribution to journalArticle

179 Citations (Scopus)

Abstract

Biomanufacturing integrates life science and engineering fundamentals to produce biocompatible products enhancing the quality of life. The state-of-the-art of this rapidly evolving manufacturing sector is presented and discussed, in particular the additive electrical, chemical and physical processes currently being applied to produce synthetic and biological parts. This fabrication strategy is strongly material-dependent, so the main classes of biomaterials are detailed. It is explained the potential to process composite materials combining synthetic and biological materials, such as cells, proteins and growth factors, as well the interdependences between materials and processes. The techniques commonly used to increase the bioactivity of clinical implants and improve the interface characteristics between biological tissues and implants are also presented.

Original languageEnglish (US)
Pages (from-to)635-655
Number of pages21
JournalCIRP Annals - Manufacturing Technology
Volume61
Issue number2
DOIs
StatePublished - Jun 27 2012

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Bioactivity
Biomaterials
Biological materials
Tissue
Proteins
Fabrication
Composite materials
Intercellular Signaling Peptides and Proteins

Keywords

  • Additive manufacturing
  • Biomedical
  • Health care

ASJC Scopus subject areas

  • Mechanical Engineering
  • Industrial and Manufacturing Engineering

Cite this

Biomedical production of implants by additive electro-chemical and physical processes. / Bartolo, Paulo; Kruth, Jean Pierre; Silva, Jorge; Levy, Gideon; Malshe, Ajay; Rajurkar, Kamlakar; Mitsuishi, Mamoru; Ciurana, Joaquim; Leu, Ming.

In: CIRP Annals - Manufacturing Technology, Vol. 61, No. 2, 27.06.2012, p. 635-655.

Research output: Contribution to journalArticle

Bartolo, P, Kruth, JP, Silva, J, Levy, G, Malshe, A, Rajurkar, K, Mitsuishi, M, Ciurana, J & Leu, M 2012, 'Biomedical production of implants by additive electro-chemical and physical processes', CIRP Annals - Manufacturing Technology, vol. 61, no. 2, pp. 635-655. https://doi.org/10.1016/j.cirp.2012.05.005
Bartolo, Paulo ; Kruth, Jean Pierre ; Silva, Jorge ; Levy, Gideon ; Malshe, Ajay ; Rajurkar, Kamlakar ; Mitsuishi, Mamoru ; Ciurana, Joaquim ; Leu, Ming. / Biomedical production of implants by additive electro-chemical and physical processes. In: CIRP Annals - Manufacturing Technology. 2012 ; Vol. 61, No. 2. pp. 635-655.
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