Biomarkers to assess the utility of potential reduced exposure tobacco products.

Dorothy K. Hatsukami, Neal L. Benowitz, Stephen Israel Rennard, Cheryl Oncken, Stephen S. Hecht

Research output: Contribution to journalReview article

20 Citations (Scopus)

Abstract

To date, we have no valid biomarkers that serve as proxies for tobacco-related disease to test potential reduced exposure products. This paper represents the deliberations of four workgroups that focused on four tobacco-related heath outcomes: Cancer, nonmalignant pulmonary disease, cardiovascular disease, and fetal toxicity. The goal of these workgroups was to identify biomarkers that offer some promise as measures of exposure or toxicity and ultimately may serve as indicators for future disease risk. Recommendations were based on the relationship of the biomarker to what is known about mechanisms of tobacco-related pathogenesis, the extent to which the biomarker differs among smokers and nonsmokers, and the sensitivity of the biomarker to changes in smoking status. Other promising biomarkers were discussed. No existing biomarkers have been demonstrated to be predictive of tobacco-related disease, which highlights the importance and urgency of conducting research in this area.

Original languageEnglish (US)
Pages (from-to)600-622
Number of pages23
JournalNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
Volume8
Issue number4
StatePublished - Jan 1 2006

Fingerprint

Tobacco Products
Biomarkers
Tobacco
Proxy
Lung Diseases
Cardiovascular Diseases
Smoking
Research
Neoplasms

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Biomarkers to assess the utility of potential reduced exposure tobacco products. / Hatsukami, Dorothy K.; Benowitz, Neal L.; Rennard, Stephen Israel; Oncken, Cheryl; Hecht, Stephen S.

In: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, Vol. 8, No. 4, 01.01.2006, p. 600-622.

Research output: Contribution to journalReview article

Hatsukami, Dorothy K. ; Benowitz, Neal L. ; Rennard, Stephen Israel ; Oncken, Cheryl ; Hecht, Stephen S. / Biomarkers to assess the utility of potential reduced exposure tobacco products. In: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 2006 ; Vol. 8, No. 4. pp. 600-622.
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