Biological Basis for the Clustering of Symptoms

Debra Lynch Kelly, Kristin A Dickinson, Chao Pin Hsiao, Nada Lukkahatai, Velda Gonzalez-Marrero, Margaret McCabe, Leorey N. Saligan

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

Objectives Identification of biologic pathways of symptom clusters is necessary to develop precision therapies for distressing symptoms. This review examined extant literature evaluating relationships between biomarkers and symptom clusters in cancer survivors. Data Sources PubMed, CINAHL, Web of Science and Cochrane Library were searched using terms “biological markers” or “biomarkers” and “symptom cluster” or “symptom complex” or “multiple symptoms.” Conclusion Biomarkers related to inflammation (eg, cytokines) were the most studied and showed the most significant relationships with clusters of symptoms. This review suggests that clustering of symptoms related to cancer or cancer therapy is linked to immune/inflammatory pathways. Implications for Nursing Practice Understanding the etiology of symptom clusters may guide future nursing interventions for symptom management.

Original languageEnglish (US)
Pages (from-to)351-360
Number of pages10
JournalSeminars in oncology nursing
Volume32
Issue number4
DOIs
StatePublished - Nov 1 2016

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Cluster Analysis
Biomarkers
Nursing
Library Science
Neoplasms
Information Storage and Retrieval
PubMed
Cytokines
Inflammation
Therapeutics

Keywords

  • biological
  • cancer-related symptoms
  • inflammation
  • pathways
  • symptom cluster
  • symptom complex

ASJC Scopus subject areas

  • Oncology(nursing)

Cite this

Lynch Kelly, D., Dickinson, K. A., Hsiao, C. P., Lukkahatai, N., Gonzalez-Marrero, V., McCabe, M., & Saligan, L. N. (2016). Biological Basis for the Clustering of Symptoms. Seminars in oncology nursing, 32(4), 351-360. https://doi.org/10.1016/j.soncn.2016.08.002

Biological Basis for the Clustering of Symptoms. / Lynch Kelly, Debra; Dickinson, Kristin A; Hsiao, Chao Pin; Lukkahatai, Nada; Gonzalez-Marrero, Velda; McCabe, Margaret; Saligan, Leorey N.

In: Seminars in oncology nursing, Vol. 32, No. 4, 01.11.2016, p. 351-360.

Research output: Contribution to journalReview article

Lynch Kelly, D, Dickinson, KA, Hsiao, CP, Lukkahatai, N, Gonzalez-Marrero, V, McCabe, M & Saligan, LN 2016, 'Biological Basis for the Clustering of Symptoms', Seminars in oncology nursing, vol. 32, no. 4, pp. 351-360. https://doi.org/10.1016/j.soncn.2016.08.002
Lynch Kelly D, Dickinson KA, Hsiao CP, Lukkahatai N, Gonzalez-Marrero V, McCabe M et al. Biological Basis for the Clustering of Symptoms. Seminars in oncology nursing. 2016 Nov 1;32(4):351-360. https://doi.org/10.1016/j.soncn.2016.08.002
Lynch Kelly, Debra ; Dickinson, Kristin A ; Hsiao, Chao Pin ; Lukkahatai, Nada ; Gonzalez-Marrero, Velda ; McCabe, Margaret ; Saligan, Leorey N. / Biological Basis for the Clustering of Symptoms. In: Seminars in oncology nursing. 2016 ; Vol. 32, No. 4. pp. 351-360.
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