Bioinformatic and Genomic Analyses of Cellular Reprogramming and Direct Lineage Conversion

Research output: Contribution to journalReview article

Abstract

Cellular reprogramming, whereby cell fate can be changed by the expression of a few defined factors, is a remarkable process that harnesses the innate ability of a cell’s own genome to rework its expressional networks and function. Since cell lineages are defined by global regulation of gene expression, transcriptional regulators, and coupled to the epigenetic markings of the chromatin, changing the cell fate necessitates broad changes to these central cellular features. To properly characterize these changes, and the mechanisms that drive them, computational and genomic approaches are perfectly suited to provide a holistic picture of the reprogramming mechanisms. In particular, the use of bioinformatic analysis has been a major driver in the study of cellular reprogramming, as it relates to both induced pluripotency or direct lineage conversion. This review will summarize many of the bioinformatic studies that have advanced our knowledge of reprogramming and address future directions for these investigations.

Original languageEnglish (US)
Pages (from-to)103-112
Number of pages10
JournalCurrent Pharmacology Reports
Volume2
Issue number3
DOIs
StatePublished - Jun 1 2016
Externally publishedYes

Fingerprint

Bioinformatics
Computational Biology
Gene expression
Chromatin
Genes
Gene Expression Regulation
Cell Lineage
Epigenomics
Genome
Cellular Reprogramming
Direction compound

Keywords

  • Bioinformatics
  • Direct lineage conversion
  • Genomics
  • Induced pluripotency
  • Reprogramming

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Biochemistry
  • Genetics

Cite this

Bioinformatic and Genomic Analyses of Cellular Reprogramming and Direct Lineage Conversion. / Kareta, Michael.

In: Current Pharmacology Reports, Vol. 2, No. 3, 01.06.2016, p. 103-112.

Research output: Contribution to journalReview article

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