Biodegradable polyanhydride-based nanomedicines for blood to brain drug delivery

Timothy M. Brenza, Benjamin W. Schlichtmann, Biju Bhargavan, Julia E. Vela Ramirez, Rainie D. Nelson, Matthew G. Panthani, JoEllyn M McMillan, Balaraman Kalyanaraman, Howard Eliot Gendelman, Vellareddy Anantharam, Anumantha G. Kanthasamy, Surya K. Mallapragada, Balaji Narasimhan, Georgette D Kanmogne

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

An urgent need to deliver therapeutics across the blood–brain barrier (BBB) underlies a paucity of effective therapies currently available for treatment of degenerative, infectious, traumatic, chemical, and metabolic disorders of the nervous system. With an eye toward achieving this goal, an in vitro BBB model was employed to simulate biodegradable polyanhydride nanoparticle-based drug delivery to the brain. Using a combination of confocal microscopy, flow cytometry, and high performance liquid chromatography, we examined the potential of polyanhydride nanoparticles containing the anti-oxidant, mito-apocynin, to be internalized and then transferred from monocytes to human brain microvascular endothelial cells. The efficacy of this nanoparticle-based delivery platform was demonstrated by neuronal protection against oxidative stress. Taken together, this polyanhydride nanoparticle-based delivery system holds promise for enhancing neuroprotection by facilitating drug transport across the BBB.

Original languageEnglish (US)
Pages (from-to)2881-2890
Number of pages10
JournalJournal of Biomedical Materials Research - Part A
Volume106
Issue number11
DOIs
StatePublished - Nov 2018

Fingerprint

Polyanhydrides
Medical nanotechnology
Drug delivery
Brain
Blood
Nanoparticles
Oxidative stress
Flow cytometry
Confocal microscopy
Endothelial cells
High performance liquid chromatography
Neurology
Oxidants
Pharmaceutical Preparations

Keywords

  • blood–brain barrier
  • cell-mediated transcytosis
  • mito-apocynin
  • nanoparticles
  • polyanhydrides

ASJC Scopus subject areas

  • Ceramics and Composites
  • Biomaterials
  • Biomedical Engineering
  • Metals and Alloys

Cite this

Brenza, T. M., Schlichtmann, B. W., Bhargavan, B., Vela Ramirez, J. E., Nelson, R. D., Panthani, M. G., ... Kanmogne, G. D. (2018). Biodegradable polyanhydride-based nanomedicines for blood to brain drug delivery. Journal of Biomedical Materials Research - Part A, 106(11), 2881-2890. https://doi.org/10.1002/jbm.a.36477

Biodegradable polyanhydride-based nanomedicines for blood to brain drug delivery. / Brenza, Timothy M.; Schlichtmann, Benjamin W.; Bhargavan, Biju; Vela Ramirez, Julia E.; Nelson, Rainie D.; Panthani, Matthew G.; McMillan, JoEllyn M; Kalyanaraman, Balaraman; Gendelman, Howard Eliot; Anantharam, Vellareddy; Kanthasamy, Anumantha G.; Mallapragada, Surya K.; Narasimhan, Balaji; Kanmogne, Georgette D.

In: Journal of Biomedical Materials Research - Part A, Vol. 106, No. 11, 11.2018, p. 2881-2890.

Research output: Contribution to journalArticle

Brenza, TM, Schlichtmann, BW, Bhargavan, B, Vela Ramirez, JE, Nelson, RD, Panthani, MG, McMillan, JM, Kalyanaraman, B, Gendelman, HE, Anantharam, V, Kanthasamy, AG, Mallapragada, SK, Narasimhan, B & Kanmogne, GD 2018, 'Biodegradable polyanhydride-based nanomedicines for blood to brain drug delivery', Journal of Biomedical Materials Research - Part A, vol. 106, no. 11, pp. 2881-2890. https://doi.org/10.1002/jbm.a.36477
Brenza TM, Schlichtmann BW, Bhargavan B, Vela Ramirez JE, Nelson RD, Panthani MG et al. Biodegradable polyanhydride-based nanomedicines for blood to brain drug delivery. Journal of Biomedical Materials Research - Part A. 2018 Nov;106(11):2881-2890. https://doi.org/10.1002/jbm.a.36477
Brenza, Timothy M. ; Schlichtmann, Benjamin W. ; Bhargavan, Biju ; Vela Ramirez, Julia E. ; Nelson, Rainie D. ; Panthani, Matthew G. ; McMillan, JoEllyn M ; Kalyanaraman, Balaraman ; Gendelman, Howard Eliot ; Anantharam, Vellareddy ; Kanthasamy, Anumantha G. ; Mallapragada, Surya K. ; Narasimhan, Balaji ; Kanmogne, Georgette D. / Biodegradable polyanhydride-based nanomedicines for blood to brain drug delivery. In: Journal of Biomedical Materials Research - Part A. 2018 ; Vol. 106, No. 11. pp. 2881-2890.
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