Biodegradable elastic nanofibrous platforms with integrated flexible heaters for on-demand drug delivery

Ali Tamayol, Alireza Hassani Najafabadi, Pooria Mostafalu, Ali K. Yetisen, Mattia Commotto, Musab Aldhahri, Mohamed Shaaban Abdel-Wahab, Zeynab Izadi Najafabadi, Shahrzad Latifi, Mohsen Akbari, Nasim Annabi, Seok Hyun Yun, Adnan Memic, Mehmet R. Dokmeci, Ali Khademhosseini

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Delivery of drugs with controlled temporal profiles is essential for wound treatment and regenerative medicine applications. For example, bacterial infection is a key challenge in the treatment of chronic and deep wounds. Current treatment strategies are based on systemic administration of high doses of antibiotics, which result in side effects and drug resistance. On-demand delivery of drugs with controlled temporal profile is highly desirable. Here, we have developed thermally controllable, antibiotic-releasing nanofibrous sheets. Poly(glycerol sebacate)- poly(caprolactone) (PGS-PCL) blends were electrospun to form elastic polymeric sheets with fiber diameters ranging from 350 to 1100 nm and substrates with a tensile modulus of approximately 4-8 MPa. A bioresorbable metallic heater was patterned directly on the nanofibrous substrate for applying thermal stimulation to release antibiotics on-demand. In vitro studies confirmed the platform's biocompatibility and biodegradability. The released antibiotics were potent against tested bacterial strains. These results may pave the path toward developing electronically controllable wound dressings that can deliver drugs with desired temporal patterns.

Original languageEnglish (US)
Article number4749
JournalScientific reports
Volume7
Issue number1
DOIs
StatePublished - Dec 1 2017

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Anti-Bacterial Agents
Pharmaceutical Preparations
Wounds and Injuries
Regenerative Medicine
Bandages
Drug-Related Side Effects and Adverse Reactions
Bacterial Infections
Drug Resistance
Hot Temperature
poly(glycerol-sebacate)
polycaprolactone
In Vitro Techniques

ASJC Scopus subject areas

  • General

Cite this

Tamayol, A., Hassani Najafabadi, A., Mostafalu, P., Yetisen, A. K., Commotto, M., Aldhahri, M., ... Khademhosseini, A. (2017). Biodegradable elastic nanofibrous platforms with integrated flexible heaters for on-demand drug delivery. Scientific reports, 7(1), [4749]. https://doi.org/10.1038/s41598-017-04749-8

Biodegradable elastic nanofibrous platforms with integrated flexible heaters for on-demand drug delivery. / Tamayol, Ali; Hassani Najafabadi, Alireza; Mostafalu, Pooria; Yetisen, Ali K.; Commotto, Mattia; Aldhahri, Musab; Abdel-Wahab, Mohamed Shaaban; Najafabadi, Zeynab Izadi; Latifi, Shahrzad; Akbari, Mohsen; Annabi, Nasim; Yun, Seok Hyun; Memic, Adnan; Dokmeci, Mehmet R.; Khademhosseini, Ali.

In: Scientific reports, Vol. 7, No. 1, 4749, 01.12.2017.

Research output: Contribution to journalArticle

Tamayol, A, Hassani Najafabadi, A, Mostafalu, P, Yetisen, AK, Commotto, M, Aldhahri, M, Abdel-Wahab, MS, Najafabadi, ZI, Latifi, S, Akbari, M, Annabi, N, Yun, SH, Memic, A, Dokmeci, MR & Khademhosseini, A 2017, 'Biodegradable elastic nanofibrous platforms with integrated flexible heaters for on-demand drug delivery', Scientific reports, vol. 7, no. 1, 4749. https://doi.org/10.1038/s41598-017-04749-8
Tamayol, Ali ; Hassani Najafabadi, Alireza ; Mostafalu, Pooria ; Yetisen, Ali K. ; Commotto, Mattia ; Aldhahri, Musab ; Abdel-Wahab, Mohamed Shaaban ; Najafabadi, Zeynab Izadi ; Latifi, Shahrzad ; Akbari, Mohsen ; Annabi, Nasim ; Yun, Seok Hyun ; Memic, Adnan ; Dokmeci, Mehmet R. ; Khademhosseini, Ali. / Biodegradable elastic nanofibrous platforms with integrated flexible heaters for on-demand drug delivery. In: Scientific reports. 2017 ; Vol. 7, No. 1.
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