Biochemistry and molecular regulation of matrix macromolecules in abdominal aortic aneurysms

Anuja Ghorpade, Bernard Timothy Baxter

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Past concepts of aneurysmal dilatation as a passive process of attenuation are oversimplified and inaccurate. Aneurysm formation is a complex remodeling process that involves both synthesis and degradation of matrix proteins. Interstitial procollagen gene expression is increased in AAA compared to AOD or normal aorta, whereas tropoelastin gene expression is decreased in both AOD and AAA. The medial elastin network is disrupted and discontinuous in small AAA. Thus, the growth rate of an established AAA may well relate to the balance between collagen synthesis and degradation. Although the increased procollagen expression found in AAA may represent a compensatory response, understanding the factors that modulate matrix metabolism in AAA may allow for development of pharmacologic strategies which effectively inhibit the growth of small aneurysms.

Original languageEnglish (US)
Pages (from-to)138-150
Number of pages13
JournalAnnals of the New York Academy of Sciences
Volume800
DOIs
StatePublished - Jan 1 1996

Fingerprint

Procollagen
Biochemistry
Abdominal Aortic Aneurysm
Macromolecules
Gene expression
Aneurysm
Tropoelastin
Gene Expression
Degradation
Elastin
Growth
Metabolism
Proteolysis
Aorta
Dilatation
Collagen
Proteins
Protein
Attenuation

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Biochemistry and molecular regulation of matrix macromolecules in abdominal aortic aneurysms. / Ghorpade, Anuja; Baxter, Bernard Timothy.

In: Annals of the New York Academy of Sciences, Vol. 800, 01.01.1996, p. 138-150.

Research output: Contribution to journalArticle

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