Biochemical and functional effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the heart of female rats

S. J. Hermansky, T. L. Holcslaw, W. J. Murray, Rodney Smith Markin, S. J. Stohs

Research output: Contribution to journalArticle

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Abstract

Biochemical, functional and morphologic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the hearts of female rats were examined. Six days after the treatment of rats with TCDD, the blood pressures and resting heart rates were significantly less than in control animals. Treated animals were also less responsive to the effects of the β-1 agonist, (-)isoproterenol. No histopathologic changes were observed in the heart although extensive centrilobular necrosis occurred in the liver after TCDD administration. Serum levels of thyroxine were 66% less than in control animals. Marked lipid peroxidation was produced in the liver with small but significant increases occurring in the heart. TCDD administration had no effect on catalase activity in the heart, but produced a 20% decrease in superoxide dismutase activity relative to control animals. The effects of TCDD on cardiac function do not appear to be due to a direct action of the xenobiotic on the heart but possibly to a down-regulation of β-receptors in the heart as a result of the hypothyroid state.

Original languageEnglish (US)
Pages (from-to)175-184
Number of pages10
JournalToxicology and Applied Pharmacology
Volume95
Issue number2
DOIs
StatePublished - Sep 15 1988

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Rats
Animals
Liver
Xenobiotics
Thyroxine
Isoproterenol
Blood pressure
Catalase
Lipid Peroxidation
Superoxide Dismutase
1,4-dioxin
Polychlorinated Dibenzodioxins
Necrosis
Down-Regulation
Heart Rate
Blood Pressure
Lipids
Serum

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

Cite this

Biochemical and functional effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the heart of female rats. / Hermansky, S. J.; Holcslaw, T. L.; Murray, W. J.; Markin, Rodney Smith; Stohs, S. J.

In: Toxicology and Applied Pharmacology, Vol. 95, No. 2, 15.09.1988, p. 175-184.

Research output: Contribution to journalArticle

Hermansky, S. J. ; Holcslaw, T. L. ; Murray, W. J. ; Markin, Rodney Smith ; Stohs, S. J. / Biochemical and functional effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the heart of female rats. In: Toxicology and Applied Pharmacology. 1988 ; Vol. 95, No. 2. pp. 175-184.
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