Bioavailability and Fate of Sediment-Associated Progesterone in Aquatic Systems

Jodi L. Sangster, Jonathan M. Ali, Daniel D Snow, Alan S Kolok, Shannon L Bartelt-Hunt

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The environmental fate and bioavailability of progesterone, a steroid hormone known to cause endocrine-disrupting effects in aquatic organisms, is of growing concern due to its occurrence in the environment in water and sediment influenced by wastewater treatment plant and paper mill effluents, as well as livestock production. The objective of this study was to evaluate the fate of progesterone in two natural sediments and the corresponding alteration of gene expression in three steroid-responsive genes; vitellogenin, androgen receptor and estrogen receptor alpha. When exposed to progesterone-spiked sand, fathead minnows (Pimephales promelas) exhibited significant reductions in the expression of vitellogenin and androgen receptor expression. In contrast, fish exposed to progesterone associated with the silty loam sediment did not show a biological response at 7 days and only realized a significant reduction in vitellogenin. In both sediments, progesterone degradation resulted in the production of androgens including androsteinedione, testosterone, and androstadienedione, as well as the antiestrogen, testolactone. Differences in compound fate resulted in organism exposure to different suites of metabolites either in water or associated with the sediment. Results from this study suggest that environmental progestagens will lead to defeminization at environmentally relevant concentrations, and that exposure is influenced by sediment properties. (Figure Presented).

Original languageEnglish (US)
Pages (from-to)4027-4036
Number of pages10
JournalEnvironmental Science and Technology
Volume50
Issue number7
DOIs
StatePublished - Apr 5 2016

Fingerprint

bioavailability
Progesterone
Sediments
androgen
sediment
Vitellogenins
steroid
Androgen Receptors
Testolactone
silty loam
Steroid hormones
sediment property
environmental fate
livestock farming
Aquatic organisms
testosterone
aquatic organism
Estrogen Receptor Modulators
Estrogen Receptor alpha
Water

ASJC Scopus subject areas

  • Chemistry(all)
  • Environmental Chemistry

Cite this

Bioavailability and Fate of Sediment-Associated Progesterone in Aquatic Systems. / Sangster, Jodi L.; Ali, Jonathan M.; Snow, Daniel D; Kolok, Alan S; Bartelt-Hunt, Shannon L.

In: Environmental Science and Technology, Vol. 50, No. 7, 05.04.2016, p. 4027-4036.

Research output: Contribution to journalArticle

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