Bilateral claudication results in alterations in the gait biomechanics at the hip and ankle joints

Shing Jye Chen, Iraklis I Pipinos, Jason M Johanning, Matija Radovic, Jessie M. Huisinga, Sara A Myers, Nicholas Stergiou

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Claudication is the most common symptomatic manifestation of peripheral arterial disease (PAD), producing significant ambulatory compromise. The purpose of this study was to use advanced biomechanical gait analysis to determine the gait alterations occurring in claudicating patients both before and after onset of claudication pain in their legs. Hip, knee, and ankle joint moments were measured in claudicating patients (age: 64.46±8.47 years; body mass: 80.70±12.64 kg; body height: 1.72±0.08 m) and were compared to gender-age-body mass-height-matched healthy controls (age 66.27±9.22 years; body mass: 77.89±10.65 kg; body height: 1.74±0.08 m). The claudicating patients were evaluated both before (pain-free (PF) condition) and after (pain condition) onset of claudication pain in their legs. Thirteen symptomatic PAD patients (26 claudicating limbs) with bilateral intermittent claudication (IC) and 11 healthy controls (22 control limbs) were tested during level walking at their self-selected speed. Compared to controls, PAD hip and ankle joints demonstrated significant angular kinematics and net internal moment changes. Alterations were present both in PF and pain conditions with several of them becoming worse in the pain condition. Both PF and pain conditions resulted in significantly reduced peak hip extensor moment (5.62±1.40 and 5.63±1.33% BW×BH, respectively) during early stance as compared to controls (7.53±1.16% BW×BH). In the pain condition, PAD patients had a significantly reduced ankle plantar flexor moment (7.56±1.41% BW×BH) during late stance as compared to controls (8.65±1.27% BW×BH). Furthermore, when comparing PF to pain conditions, there was a decreased peak plantar flexor moment (PF condition: 8.23±1.37 vs. pain condition: 7.56±1.41% BW×BH) during late stance. The findings point to a weakness in the posterior compartment muscles of the hip and calf as being the key factor underlying the PAD gait adaptations. Our findings establish a detailed baseline description of the changes present in PAD patient's joint angles and moments during walking. Since IC is primarily a gait disability, better understanding of the abnormalities in joint and muscle function will enhance our understanding of the gait impairment and may lead to novel, gait-specific treatments.

Original languageEnglish (US)
Pages (from-to)2506-2514
Number of pages9
JournalJournal of Biomechanics
Volume41
Issue number11
DOIs
StatePublished - Aug 1 2008

Fingerprint

Ankle Joint
Biomechanics
Hip Joint
Gait
Biomechanical Phenomena
Peripheral Arterial Disease
Pain
Body Height
Muscle
Intermittent Claudication
Gait analysis
Walking
Hip
Leg
Extremities
Joints
Muscles
Kinematics
Knee Joint
Ankle

Keywords

  • Biomechanics
  • Claudication
  • Gait
  • Joint moment
  • Peripheral arterial disease

ASJC Scopus subject areas

  • Biophysics
  • Orthopedics and Sports Medicine
  • Biomedical Engineering
  • Rehabilitation

Cite this

Bilateral claudication results in alterations in the gait biomechanics at the hip and ankle joints. / Chen, Shing Jye; Pipinos, Iraklis I; Johanning, Jason M; Radovic, Matija; Huisinga, Jessie M.; Myers, Sara A; Stergiou, Nicholas.

In: Journal of Biomechanics, Vol. 41, No. 11, 01.08.2008, p. 2506-2514.

Research output: Contribution to journalArticle

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abstract = "Claudication is the most common symptomatic manifestation of peripheral arterial disease (PAD), producing significant ambulatory compromise. The purpose of this study was to use advanced biomechanical gait analysis to determine the gait alterations occurring in claudicating patients both before and after onset of claudication pain in their legs. Hip, knee, and ankle joint moments were measured in claudicating patients (age: 64.46±8.47 years; body mass: 80.70±12.64 kg; body height: 1.72±0.08 m) and were compared to gender-age-body mass-height-matched healthy controls (age 66.27±9.22 years; body mass: 77.89±10.65 kg; body height: 1.74±0.08 m). The claudicating patients were evaluated both before (pain-free (PF) condition) and after (pain condition) onset of claudication pain in their legs. Thirteen symptomatic PAD patients (26 claudicating limbs) with bilateral intermittent claudication (IC) and 11 healthy controls (22 control limbs) were tested during level walking at their self-selected speed. Compared to controls, PAD hip and ankle joints demonstrated significant angular kinematics and net internal moment changes. Alterations were present both in PF and pain conditions with several of them becoming worse in the pain condition. Both PF and pain conditions resulted in significantly reduced peak hip extensor moment (5.62±1.40 and 5.63±1.33{\%} BW×BH, respectively) during early stance as compared to controls (7.53±1.16{\%} BW×BH). In the pain condition, PAD patients had a significantly reduced ankle plantar flexor moment (7.56±1.41{\%} BW×BH) during late stance as compared to controls (8.65±1.27{\%} BW×BH). Furthermore, when comparing PF to pain conditions, there was a decreased peak plantar flexor moment (PF condition: 8.23±1.37 vs. pain condition: 7.56±1.41{\%} BW×BH) during late stance. The findings point to a weakness in the posterior compartment muscles of the hip and calf as being the key factor underlying the PAD gait adaptations. Our findings establish a detailed baseline description of the changes present in PAD patient's joint angles and moments during walking. Since IC is primarily a gait disability, better understanding of the abnormalities in joint and muscle function will enhance our understanding of the gait impairment and may lead to novel, gait-specific treatments.",
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