Bilateral activation of the prefrontal cortex after strategic semantic cognitive training

Eliane C. Miotto, Cary R. Savage, Jonathan J. Evans, Barbara A. Wilson, M. G.M. Martins, Suzan Iaki, Edson Amaro

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

The prefrontal cortex (PFC) has been implicated in the ability to apply semantic organizational strategies during verbal encoding and episodic learning. However, there has been no direct evidence demonstrating which specific areas in the PFC are engaged after cognitive training using semantic organizational strategies in healthy adult human subjects. In this study, we investigated the effects of semantic strategic training on brain activity and changes in behavioral performance, after cognitive training, using functional MRI (fMRI). There was a significant activation in bilateral dorsolateral prefrontal (DLPF) and orbitofrontal (OFC) areas after cognitive training. These results demonstrate the engagement of bilateral DLPF and OFC cortex during strategic memory processes, particularly when mobilization and effort of effective use of strategies are required. The functional adaptations observed here may also shed light on some of the processes underlying recovery with cognitive rehabilitation in patient populations with brain injury.

Original languageEnglish (US)
Pages (from-to)288-295
Number of pages8
JournalHuman Brain Mapping
Volume27
Issue number4
DOIs
StatePublished - Apr 2006

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Prefrontal Cortex
Semantics
Aptitude
Brain Injuries
Rehabilitation
Magnetic Resonance Imaging
Learning
Brain
Population

Keywords

  • Cognitive training
  • Prefrontal
  • Strategy
  • fMRI

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

Cite this

Miotto, E. C., Savage, C. R., Evans, J. J., Wilson, B. A., Martins, M. G. M., Iaki, S., & Amaro, E. (2006). Bilateral activation of the prefrontal cortex after strategic semantic cognitive training. Human Brain Mapping, 27(4), 288-295. https://doi.org/10.1002/hbm.20184

Bilateral activation of the prefrontal cortex after strategic semantic cognitive training. / Miotto, Eliane C.; Savage, Cary R.; Evans, Jonathan J.; Wilson, Barbara A.; Martins, M. G.M.; Iaki, Suzan; Amaro, Edson.

In: Human Brain Mapping, Vol. 27, No. 4, 04.2006, p. 288-295.

Research output: Contribution to journalArticle

Miotto, EC, Savage, CR, Evans, JJ, Wilson, BA, Martins, MGM, Iaki, S & Amaro, E 2006, 'Bilateral activation of the prefrontal cortex after strategic semantic cognitive training', Human Brain Mapping, vol. 27, no. 4, pp. 288-295. https://doi.org/10.1002/hbm.20184
Miotto, Eliane C. ; Savage, Cary R. ; Evans, Jonathan J. ; Wilson, Barbara A. ; Martins, M. G.M. ; Iaki, Suzan ; Amaro, Edson. / Bilateral activation of the prefrontal cortex after strategic semantic cognitive training. In: Human Brain Mapping. 2006 ; Vol. 27, No. 4. pp. 288-295.
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