Abstract
At least some retinal axons afferent to the hypothalamic suprachiasmatic nucleus (SCN; a circadian oscillator) bifurcate in the optic chiasm (O.E. Millhouse, Brain Res., 137 (1977) 351-355). The termination site(s) of the axonal branch that continues in the optic tract is unknown. Injection of the fluorescent tracer, True Blue, into the SCN and the fluorescent dye, Nuclear Yellow, into the lateral geniculate complex resulted in the labeling of individual retinal ganglion cells with both tracers. However, only Nuclear Yellow injections which included the intergeniculate leaflet (IGL) resulted in double-labeled ganglion cells in the retinate. These results indicate that individual retinal ganglion cells innervate both the hypothalamic SCN and the IGL of the thalamus by means of divergent axonal collaterals. Moreover, neurons of the IGL are afferent to the SCN, thereby forming a complex circuit within which photic information from the same retinal ganglion cell may influence the SCN both directly and after thalamic processing.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 211-217 |
| Number of pages | 7 |
| Journal | Neuroscience Letters |
| Volume | 55 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 9 1985 |
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Keywords
- axonal collateral
- circadian rhythm
- double-label
- intergeniculate leaflet
- retinal ganglion cell
- suprachiasmatic nucleus
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Bifurcating axons of retinal ganglion cells terminate in the hypothalamic suppachiasmatic nucleus and the intergeniculate leaflet of the thalamus. / Pickard, Gary E.
In: Neuroscience Letters, Vol. 55, No. 2, 09.04.1985, p. 211-217.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Bifurcating axons of retinal ganglion cells terminate in the hypothalamic suppachiasmatic nucleus and the intergeniculate leaflet of the thalamus
AU - Pickard, Gary E.
PY - 1985/4/9
Y1 - 1985/4/9
N2 - At least some retinal axons afferent to the hypothalamic suprachiasmatic nucleus (SCN; a circadian oscillator) bifurcate in the optic chiasm (O.E. Millhouse, Brain Res., 137 (1977) 351-355). The termination site(s) of the axonal branch that continues in the optic tract is unknown. Injection of the fluorescent tracer, True Blue, into the SCN and the fluorescent dye, Nuclear Yellow, into the lateral geniculate complex resulted in the labeling of individual retinal ganglion cells with both tracers. However, only Nuclear Yellow injections which included the intergeniculate leaflet (IGL) resulted in double-labeled ganglion cells in the retinate. These results indicate that individual retinal ganglion cells innervate both the hypothalamic SCN and the IGL of the thalamus by means of divergent axonal collaterals. Moreover, neurons of the IGL are afferent to the SCN, thereby forming a complex circuit within which photic information from the same retinal ganglion cell may influence the SCN both directly and after thalamic processing.
AB - At least some retinal axons afferent to the hypothalamic suprachiasmatic nucleus (SCN; a circadian oscillator) bifurcate in the optic chiasm (O.E. Millhouse, Brain Res., 137 (1977) 351-355). The termination site(s) of the axonal branch that continues in the optic tract is unknown. Injection of the fluorescent tracer, True Blue, into the SCN and the fluorescent dye, Nuclear Yellow, into the lateral geniculate complex resulted in the labeling of individual retinal ganglion cells with both tracers. However, only Nuclear Yellow injections which included the intergeniculate leaflet (IGL) resulted in double-labeled ganglion cells in the retinate. These results indicate that individual retinal ganglion cells innervate both the hypothalamic SCN and the IGL of the thalamus by means of divergent axonal collaterals. Moreover, neurons of the IGL are afferent to the SCN, thereby forming a complex circuit within which photic information from the same retinal ganglion cell may influence the SCN both directly and after thalamic processing.
KW - axonal collateral
KW - circadian rhythm
KW - double-label
KW - intergeniculate leaflet
KW - retinal ganglion cell
KW - suprachiasmatic nucleus
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UR - http://www.scopus.com/inward/citedby.url?scp=0021999540&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(85)90022-9
DO - 10.1016/0304-3940(85)90022-9
M3 - Article
C2 - 4000547
AN - SCOPUS:0021999540
VL - 55
SP - 211
EP - 217
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 2
ER -