Bifurcating axons of retinal ganglion cells terminate in the hypothalamic suppachiasmatic nucleus and the intergeniculate leaflet of the thalamus

Research output: Contribution to journalArticle

213 Citations (Scopus)

Abstract

At least some retinal axons afferent to the hypothalamic suprachiasmatic nucleus (SCN; a circadian oscillator) bifurcate in the optic chiasm (O.E. Millhouse, Brain Res., 137 (1977) 351-355). The termination site(s) of the axonal branch that continues in the optic tract is unknown. Injection of the fluorescent tracer, True Blue, into the SCN and the fluorescent dye, Nuclear Yellow, into the lateral geniculate complex resulted in the labeling of individual retinal ganglion cells with both tracers. However, only Nuclear Yellow injections which included the intergeniculate leaflet (IGL) resulted in double-labeled ganglion cells in the retinate. These results indicate that individual retinal ganglion cells innervate both the hypothalamic SCN and the IGL of the thalamus by means of divergent axonal collaterals. Moreover, neurons of the IGL are afferent to the SCN, thereby forming a complex circuit within which photic information from the same retinal ganglion cell may influence the SCN both directly and after thalamic processing.

Original languageEnglish (US)
Pages (from-to)211-217
Number of pages7
JournalNeuroscience Letters
Volume55
Issue number2
DOIs
StatePublished - Apr 9 1985

Fingerprint

nuclear yellow
Retinal Ganglion Cells
Thalamus
Axons
Optic Chiasm
Suprachiasmatic Nucleus
Injections
Fluorescent Dyes
Ganglia
Neurons
Brain

Keywords

  • axonal collateral
  • circadian rhythm
  • double-label
  • intergeniculate leaflet
  • retinal ganglion cell
  • suprachiasmatic nucleus

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

@article{cfac4604a897450f8637fe807d22d3db,
title = "Bifurcating axons of retinal ganglion cells terminate in the hypothalamic suppachiasmatic nucleus and the intergeniculate leaflet of the thalamus",
abstract = "At least some retinal axons afferent to the hypothalamic suprachiasmatic nucleus (SCN; a circadian oscillator) bifurcate in the optic chiasm (O.E. Millhouse, Brain Res., 137 (1977) 351-355). The termination site(s) of the axonal branch that continues in the optic tract is unknown. Injection of the fluorescent tracer, True Blue, into the SCN and the fluorescent dye, Nuclear Yellow, into the lateral geniculate complex resulted in the labeling of individual retinal ganglion cells with both tracers. However, only Nuclear Yellow injections which included the intergeniculate leaflet (IGL) resulted in double-labeled ganglion cells in the retinate. These results indicate that individual retinal ganglion cells innervate both the hypothalamic SCN and the IGL of the thalamus by means of divergent axonal collaterals. Moreover, neurons of the IGL are afferent to the SCN, thereby forming a complex circuit within which photic information from the same retinal ganglion cell may influence the SCN both directly and after thalamic processing.",
keywords = "axonal collateral, circadian rhythm, double-label, intergeniculate leaflet, retinal ganglion cell, suprachiasmatic nucleus",
author = "Pickard, {Gary E.}",
year = "1985",
month = "4",
day = "9",
doi = "10.1016/0304-3940(85)90022-9",
language = "English (US)",
volume = "55",
pages = "211--217",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Bifurcating axons of retinal ganglion cells terminate in the hypothalamic suppachiasmatic nucleus and the intergeniculate leaflet of the thalamus

AU - Pickard, Gary E.

PY - 1985/4/9

Y1 - 1985/4/9

N2 - At least some retinal axons afferent to the hypothalamic suprachiasmatic nucleus (SCN; a circadian oscillator) bifurcate in the optic chiasm (O.E. Millhouse, Brain Res., 137 (1977) 351-355). The termination site(s) of the axonal branch that continues in the optic tract is unknown. Injection of the fluorescent tracer, True Blue, into the SCN and the fluorescent dye, Nuclear Yellow, into the lateral geniculate complex resulted in the labeling of individual retinal ganglion cells with both tracers. However, only Nuclear Yellow injections which included the intergeniculate leaflet (IGL) resulted in double-labeled ganglion cells in the retinate. These results indicate that individual retinal ganglion cells innervate both the hypothalamic SCN and the IGL of the thalamus by means of divergent axonal collaterals. Moreover, neurons of the IGL are afferent to the SCN, thereby forming a complex circuit within which photic information from the same retinal ganglion cell may influence the SCN both directly and after thalamic processing.

AB - At least some retinal axons afferent to the hypothalamic suprachiasmatic nucleus (SCN; a circadian oscillator) bifurcate in the optic chiasm (O.E. Millhouse, Brain Res., 137 (1977) 351-355). The termination site(s) of the axonal branch that continues in the optic tract is unknown. Injection of the fluorescent tracer, True Blue, into the SCN and the fluorescent dye, Nuclear Yellow, into the lateral geniculate complex resulted in the labeling of individual retinal ganglion cells with both tracers. However, only Nuclear Yellow injections which included the intergeniculate leaflet (IGL) resulted in double-labeled ganglion cells in the retinate. These results indicate that individual retinal ganglion cells innervate both the hypothalamic SCN and the IGL of the thalamus by means of divergent axonal collaterals. Moreover, neurons of the IGL are afferent to the SCN, thereby forming a complex circuit within which photic information from the same retinal ganglion cell may influence the SCN both directly and after thalamic processing.

KW - axonal collateral

KW - circadian rhythm

KW - double-label

KW - intergeniculate leaflet

KW - retinal ganglion cell

KW - suprachiasmatic nucleus

UR - http://www.scopus.com/inward/record.url?scp=0021999540&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021999540&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(85)90022-9

DO - 10.1016/0304-3940(85)90022-9

M3 - Article

C2 - 4000547

AN - SCOPUS:0021999540

VL - 55

SP - 211

EP - 217

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 2

ER -