Beyond oncology - Application of HPMA copolymers in non-cancerous diseases

Xin Ming Liu, Scott C. Miller, Dong Wang

Research output: Contribution to journalReview article

28 Citations (Scopus)

Abstract

Macromolecular drug conjugates have been developed to improve the efficacy and safety profile of various therapeutic agents for many years. Among them, N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-drug conjugates are the most extensively studied delivery platforms for the effective treatment of cancer. In recent years, the applications of HPMA copolymers for the treatment of a broader range of non-cancerous diseases have also been explored. This review highlights the recent developments in the rational design, synthesis, and evaluation of novel HPMA copolymer-drug conjugates for non-cancerous diseases, such as musculoskeletal diseases, infectious diseases and spinal cord injury. The translation potential of these applications is also briefly discussed.

Original languageEnglish (US)
Pages (from-to)258-271
Number of pages14
JournalAdvanced Drug Delivery Reviews
Volume62
Issue number2
DOIs
StatePublished - Feb 17 2010

Fingerprint

Pharmaceutical Preparations
Musculoskeletal Diseases
Spinal Cord Injuries
Communicable Diseases
Safety
N-(2-hydroxypropyl)methacrylamide
Neoplasms
Therapeutics

Keywords

  • Arthritis
  • Bone-targeting
  • Central nervous system (CNS)
  • HPMA copolymers
  • Infectious diseases
  • Musculoskeletal diseases

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Beyond oncology - Application of HPMA copolymers in non-cancerous diseases. / Liu, Xin Ming; Miller, Scott C.; Wang, Dong.

In: Advanced Drug Delivery Reviews, Vol. 62, No. 2, 17.02.2010, p. 258-271.

Research output: Contribution to journalReview article

Liu, Xin Ming ; Miller, Scott C. ; Wang, Dong. / Beyond oncology - Application of HPMA copolymers in non-cancerous diseases. In: Advanced Drug Delivery Reviews. 2010 ; Vol. 62, No. 2. pp. 258-271.
@article{caa15f64c0ad4efcb9b18ea2af453aee,
title = "Beyond oncology - Application of HPMA copolymers in non-cancerous diseases",
abstract = "Macromolecular drug conjugates have been developed to improve the efficacy and safety profile of various therapeutic agents for many years. Among them, N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-drug conjugates are the most extensively studied delivery platforms for the effective treatment of cancer. In recent years, the applications of HPMA copolymers for the treatment of a broader range of non-cancerous diseases have also been explored. This review highlights the recent developments in the rational design, synthesis, and evaluation of novel HPMA copolymer-drug conjugates for non-cancerous diseases, such as musculoskeletal diseases, infectious diseases and spinal cord injury. The translation potential of these applications is also briefly discussed.",
keywords = "Arthritis, Bone-targeting, Central nervous system (CNS), HPMA copolymers, Infectious diseases, Musculoskeletal diseases",
author = "Liu, {Xin Ming} and Miller, {Scott C.} and Dong Wang",
year = "2010",
month = "2",
day = "17",
doi = "10.1016/j.addr.2009.10.006",
language = "English (US)",
volume = "62",
pages = "258--271",
journal = "Advanced Drug Delivery Reviews",
issn = "0169-409X",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Beyond oncology - Application of HPMA copolymers in non-cancerous diseases

AU - Liu, Xin Ming

AU - Miller, Scott C.

AU - Wang, Dong

PY - 2010/2/17

Y1 - 2010/2/17

N2 - Macromolecular drug conjugates have been developed to improve the efficacy and safety profile of various therapeutic agents for many years. Among them, N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-drug conjugates are the most extensively studied delivery platforms for the effective treatment of cancer. In recent years, the applications of HPMA copolymers for the treatment of a broader range of non-cancerous diseases have also been explored. This review highlights the recent developments in the rational design, synthesis, and evaluation of novel HPMA copolymer-drug conjugates for non-cancerous diseases, such as musculoskeletal diseases, infectious diseases and spinal cord injury. The translation potential of these applications is also briefly discussed.

AB - Macromolecular drug conjugates have been developed to improve the efficacy and safety profile of various therapeutic agents for many years. Among them, N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-drug conjugates are the most extensively studied delivery platforms for the effective treatment of cancer. In recent years, the applications of HPMA copolymers for the treatment of a broader range of non-cancerous diseases have also been explored. This review highlights the recent developments in the rational design, synthesis, and evaluation of novel HPMA copolymer-drug conjugates for non-cancerous diseases, such as musculoskeletal diseases, infectious diseases and spinal cord injury. The translation potential of these applications is also briefly discussed.

KW - Arthritis

KW - Bone-targeting

KW - Central nervous system (CNS)

KW - HPMA copolymers

KW - Infectious diseases

KW - Musculoskeletal diseases

UR - http://www.scopus.com/inward/record.url?scp=75749129808&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=75749129808&partnerID=8YFLogxK

U2 - 10.1016/j.addr.2009.10.006

DO - 10.1016/j.addr.2009.10.006

M3 - Review article

VL - 62

SP - 258

EP - 271

JO - Advanced Drug Delivery Reviews

JF - Advanced Drug Delivery Reviews

SN - 0169-409X

IS - 2

ER -