Betaine, ethanol, and the liver

A review

Anthony J. Barak, Harriet C. Beckenhauer, Dean J. Tuma

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

Two of the most important biochemical hepatic pathways in the liver are those that synthesize methionine and S adenosylmethionine (SAM) through the methylation of homocysteine. This article reviews some recent findings in this laboratory, which demonstrate that ethanol feeding to rats impairs one of these pathways involving the enzyme methionine synthetase (MS), but by way of compensation increases the activity of the enzyme betaine:homocysteine methyl transferase (BHMT), which catalyzes the second pathway in methionine and SAM biosynthesis. It has been shown that despite the inhibition of MS, the enhanced BHMT pathway utilizes hepatic betaine pools to maintain levels of SAM. Subsequent to the above findings, it has been shown that minimal supplemental dietary betaine at the 0.5% level generates SAM twofold in control animals and fivefold in ethanol-fed rats. Concomitant with the betaine-generated SAM, ethanol-induced hepatic fatty infiltration was ameliorated. In view of the fact that SAM has already been used successfully in the treatment of human maladies, including liver dysfunction, betaine, shown to protect against the early stages of alcoholic liver injury as well as being a SAM generator, may become a promising therapeutic agent and a possible alternative to expensive SAM in the treatment of liver disease and other human maladies.

Original languageEnglish (US)
Pages (from-to)395-398
Number of pages4
JournalAlcohol
Volume13
Issue number4
DOIs
StatePublished - Jul 1996
Externally publishedYes

Fingerprint

S-Adenosylmethionine
Betaine
subversion
alcoholism
Liver
Ethanol
animal
Disease
Homocysteine
5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Transferases
Methionine
Rats
Liver Diseases
Methylation
Biosynthesis
Enzymes
Infiltration
Animals
Wounds and Injuries

Keywords

  • Betaine
  • Ethanol
  • Liver
  • Methionine metabolism
  • Rats
  • S-Adenosylmethionine

ASJC Scopus subject areas

  • Biochemistry
  • Medicine(all)
  • Behavioral Neuroscience
  • Neuroscience(all)
  • Toxicology
  • Health(social science)

Cite this

Barak, A. J., Beckenhauer, H. C., & Tuma, D. J. (1996). Betaine, ethanol, and the liver: A review. Alcohol, 13(4), 395-398. https://doi.org/10.1016/0741-8329(96)00030-4

Betaine, ethanol, and the liver : A review. / Barak, Anthony J.; Beckenhauer, Harriet C.; Tuma, Dean J.

In: Alcohol, Vol. 13, No. 4, 07.1996, p. 395-398.

Research output: Contribution to journalArticle

Barak, AJ, Beckenhauer, HC & Tuma, DJ 1996, 'Betaine, ethanol, and the liver: A review', Alcohol, vol. 13, no. 4, pp. 395-398. https://doi.org/10.1016/0741-8329(96)00030-4
Barak AJ, Beckenhauer HC, Tuma DJ. Betaine, ethanol, and the liver: A review. Alcohol. 1996 Jul;13(4):395-398. https://doi.org/10.1016/0741-8329(96)00030-4
Barak, Anthony J. ; Beckenhauer, Harriet C. ; Tuma, Dean J. / Betaine, ethanol, and the liver : A review. In: Alcohol. 1996 ; Vol. 13, No. 4. pp. 395-398.
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