Betaine effects on hepatic methionine metabolism elicited by short-term ethanol feeding

Anthony J. Barak, Harriet C. Beckenhauer, Dean J Tuma

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Previous studies in this laboratory have shown that feeding of ethanol to rats produces prompt inhibition of methionine synthetase (MS) as well as a subsequent increase in activity of betaine homocysteine methyltransferase (BHMT). Further studies have shown that supplemental dietary betaine enhanced methionine metabolism and S-adenosylmethionine (SAM) generation in control and ethanol-fed rats. Because MS and BHMT are both involved in the formation of SAM. This study was conducted to determine early of effects of ethanol on hepatic SAM levels and the influence of betaine supplementation on parameters of methionine metabolism during the early periods of MS inhibition and enhanced BHMT activity. Results showed that ethanol feeding produced a significant loss in SAM in the first week with a return to normal SAM levels in the second week. Betaine feeding enhanced hepatic betaine pools in control as well as ethanol-fed animals. This feeding attenuated the early loss of SAM in ethanol fed animals, produced an early increase in BHMT activity, and generated increased levels of SAM in both control and ethanol-fed groups. Furthermore, betaine lowered significantly the accumulation of hepatic triglyceride produced by ethanol after 2 weeks of ingestion.

Original languageEnglish (US)
Pages (from-to)483-486
Number of pages4
JournalAlcohol
Volume13
Issue number5
DOIs
StatePublished - Jan 1 1996

Fingerprint

Betaine
S-Adenosylmethionine
Metabolism
Methionine
Betaine-Homocysteine S-Methyltransferase
Ethanol
Liver
5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
animal
Rats
Animals
Enzyme inhibition
Group
Triglycerides
Eating

Keywords

  • Betaine
  • Ethanol
  • Liver
  • Methionine metabolism
  • Rats
  • S-Adenosylmethionine

ASJC Scopus subject areas

  • Health(social science)
  • Biochemistry
  • Toxicology
  • Neurology
  • Behavioral Neuroscience

Cite this

Betaine effects on hepatic methionine metabolism elicited by short-term ethanol feeding. / Barak, Anthony J.; Beckenhauer, Harriet C.; Tuma, Dean J.

In: Alcohol, Vol. 13, No. 5, 01.01.1996, p. 483-486.

Research output: Contribution to journalArticle

Barak, Anthony J. ; Beckenhauer, Harriet C. ; Tuma, Dean J. / Betaine effects on hepatic methionine metabolism elicited by short-term ethanol feeding. In: Alcohol. 1996 ; Vol. 13, No. 5. pp. 483-486.
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