Berberine derivatives as antileishmanial drugs

J. L. Vennerstrom, J. K. Lovelace, V. B. Waits, W. L. Hanson, D. L. Klayman

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Abstract

Berberine, a quaternary alkaloid, and several of its derivatives were tested for efficacy against Leishmania donovani and Leishmania braziliensis panamensis in golden hamsters. Tetrahydroberberine was less toxic and more potent than berberine against L. donovani but was not potent as meglumine antimonate (Glucantime), a standard drug for the treatment of leishmaniasis. Only berberine and 8-cyanodihydroberberine showed significant activity (> 50% suppression of lesion size) against L. braziliensis panamensis.

Original languageEnglish (US)
Pages (from-to)918-921
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume34
Issue number5
DOIs
StatePublished - Jan 1 1990

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ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Vennerstrom, J. L., Lovelace, J. K., Waits, V. B., Hanson, W. L., & Klayman, D. L. (1990). Berberine derivatives as antileishmanial drugs. Antimicrobial Agents and Chemotherapy, 34(5), 918-921. https://doi.org/10.1128/AAC.34.5.918