Berberine derivatives as antileishmanial drugs

J. L. Vennerstrom, J. K. Lovelace, V. B. Waits, W. L. Hanson, D. L. Klayman

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Berberine, a quaternary alkaloid, and several of its derivatives were tested for efficacy against Leishmania donovani and Leishmania braziliensis panamensis in golden hamsters. Tetrahydroberberine was less toxic and more potent than berberine against L. donovani but was not potent as meglumine antimonate (Glucantime), a standard drug for the treatment of leishmaniasis. Only berberine and 8-cyanodihydroberberine showed significant activity (> 50% suppression of lesion size) against L. braziliensis panamensis.

Original languageEnglish (US)
Pages (from-to)918-921
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume34
Issue number5
DOIs
StatePublished - Jan 1 1990

Fingerprint

Berberine
Leishmania braziliensis
Leishmania donovani
Pharmaceutical Preparations
Meglumine
Leishmaniasis
Poisons
Mesocricetus
Alkaloids

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Vennerstrom, J. L., Lovelace, J. K., Waits, V. B., Hanson, W. L., & Klayman, D. L. (1990). Berberine derivatives as antileishmanial drugs. Antimicrobial Agents and Chemotherapy, 34(5), 918-921. https://doi.org/10.1128/AAC.34.5.918

Berberine derivatives as antileishmanial drugs. / Vennerstrom, J. L.; Lovelace, J. K.; Waits, V. B.; Hanson, W. L.; Klayman, D. L.

In: Antimicrobial Agents and Chemotherapy, Vol. 34, No. 5, 01.01.1990, p. 918-921.

Research output: Contribution to journalArticle

Vennerstrom, JL, Lovelace, JK, Waits, VB, Hanson, WL & Klayman, DL 1990, 'Berberine derivatives as antileishmanial drugs', Antimicrobial Agents and Chemotherapy, vol. 34, no. 5, pp. 918-921. https://doi.org/10.1128/AAC.34.5.918
Vennerstrom, J. L. ; Lovelace, J. K. ; Waits, V. B. ; Hanson, W. L. ; Klayman, D. L. / Berberine derivatives as antileishmanial drugs. In: Antimicrobial Agents and Chemotherapy. 1990 ; Vol. 34, No. 5. pp. 918-921.
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