Abstract
Benign nevus cell aggregates (NCAs) in lymph nodes usually present as intracapsular or trabecular collections of small, uniform melanocytes that resemble those seen in intradermal melanocytic nevi. The surgical pathologist must be aware of nodal NCAs because they can mimic micrometastasis of carcinoma. Although not uncommon, the frequency with which NCAs occur is controversial. Two previous studies attempted to determine the case incidence of NCAs in axillary lymphadenectomies; widely different results were reported, ranging from .33% to 6.2%. In this study, the authors examined prospectively 300 axillary lymph node dissections containing 5186 lymph nodes, using S-100 protein immunohistochemistry as a supplemental evaluation measure, to determine the incidence of NCAs. Twenty-eight NCA-positive lymph nodes from 22 cases were found, for a 7.3% case incidence and a .54% nodal incidence; these figures were higher than those previously reported. The possible pathogenesis of this phenomenon is discussed, with a review of the literature.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 102-108 |
| Number of pages | 7 |
| Journal | American journal of clinical pathology |
| Volume | 102 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 1994 |
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Keywords
- Axillary lymph nodes
- Blue nevus
- Malignant melanoma
- Melanocytic nevus
- Metastatic breast carcinoma
- Nevus cell aggregates
- S-100 protein
ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
Benign melanocytic nevus cells in axillary lymph nodes : A prospective incidence and immunohistochemical study with literature review. / Bautista, N. C.; Cohen, S.; Anders, K. H.
In: American journal of clinical pathology, Vol. 102, No. 1, 01.01.1994, p. 102-108.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Benign melanocytic nevus cells in axillary lymph nodes
T2 - A prospective incidence and immunohistochemical study with literature review
AU - Bautista, N. C.
AU - Cohen, S.
AU - Anders, K. H.
PY - 1994/1/1
Y1 - 1994/1/1
N2 - Benign nevus cell aggregates (NCAs) in lymph nodes usually present as intracapsular or trabecular collections of small, uniform melanocytes that resemble those seen in intradermal melanocytic nevi. The surgical pathologist must be aware of nodal NCAs because they can mimic micrometastasis of carcinoma. Although not uncommon, the frequency with which NCAs occur is controversial. Two previous studies attempted to determine the case incidence of NCAs in axillary lymphadenectomies; widely different results were reported, ranging from .33% to 6.2%. In this study, the authors examined prospectively 300 axillary lymph node dissections containing 5186 lymph nodes, using S-100 protein immunohistochemistry as a supplemental evaluation measure, to determine the incidence of NCAs. Twenty-eight NCA-positive lymph nodes from 22 cases were found, for a 7.3% case incidence and a .54% nodal incidence; these figures were higher than those previously reported. The possible pathogenesis of this phenomenon is discussed, with a review of the literature.
AB - Benign nevus cell aggregates (NCAs) in lymph nodes usually present as intracapsular or trabecular collections of small, uniform melanocytes that resemble those seen in intradermal melanocytic nevi. The surgical pathologist must be aware of nodal NCAs because they can mimic micrometastasis of carcinoma. Although not uncommon, the frequency with which NCAs occur is controversial. Two previous studies attempted to determine the case incidence of NCAs in axillary lymphadenectomies; widely different results were reported, ranging from .33% to 6.2%. In this study, the authors examined prospectively 300 axillary lymph node dissections containing 5186 lymph nodes, using S-100 protein immunohistochemistry as a supplemental evaluation measure, to determine the incidence of NCAs. Twenty-eight NCA-positive lymph nodes from 22 cases were found, for a 7.3% case incidence and a .54% nodal incidence; these figures were higher than those previously reported. The possible pathogenesis of this phenomenon is discussed, with a review of the literature.
KW - Axillary lymph nodes
KW - Blue nevus
KW - Malignant melanoma
KW - Melanocytic nevus
KW - Metastatic breast carcinoma
KW - Nevus cell aggregates
KW - S-100 protein
UR - http://www.scopus.com/inward/record.url?scp=0028071864&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028071864&partnerID=8YFLogxK
U2 - 10.1093/ajcp/102.1.102
DO - 10.1093/ajcp/102.1.102
M3 - Article
C2 - 8037154
AN - SCOPUS:0028071864
VL - 102
SP - 102
EP - 108
JO - American Journal of Clinical Pathology
JF - American Journal of Clinical Pathology
SN - 0002-9173
IS - 1
ER -