Bench-to-bedside translation of magnetic nanoparticles

Dhirender Singh, Jo Ellyn M. Mcmillan, Alexander V. Kabanov, Marina Sokolsky-Papkov, Howard E. Gendelman

Research output: Contribution to journalReview article

42 Scopus citations

Abstract

Magnetic nanoparticles (MNPs) are a new and promising addition to the spectrum of biomedicines. Their promise revolves around the broad versatility and biocompatibility of the MNPs and their unique physicochemical properties. Guided by applied external magnetic fields, MNPs represent a cutting-edge tool designed to improve diagnosis and therapy of a broad range of inflammatory, infectious, genetic and degenerative diseases. Magnetic hyperthermia, targeted drug and gene delivery, cell tracking, protein bioseparation and tissue engineering are but a few applications being developed for MNPs. MNPs toxicities linked to shape, size and surface chemistry are real and must be addressed before clinical use is realized. This article presents both the promise and perils of this new nanotechnology, with an eye towards opportunity in translational medical science.

Original languageEnglish (US)
Pages (from-to)501-516
Number of pages16
JournalNanomedicine
Volume9
Issue number4
DOIs
StatePublished - Mar 2014

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Keywords

  • MRI
  • biocompatibility
  • drug targeting
  • magnetic hyperthermia
  • nanoparticle
  • targeted drug and gene delivery
  • tissue engineering

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Materials Science(all)

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