Barriers to glaucoma drug delivery

Deepta A Ghate, Henry F. Edelhauser

Research output: Contribution to journalReview article

79 Citations (Scopus)

Abstract

Topical medications remain the mainstay of glaucoma treatment. This review will aim to cover the pharmacokinetics of topically applied drops, the ocular barriers to drug delivery, and the role of ophthalmic drug formulation in enhancing drug delivery to the target tissue while minimizing side effects and increasing patient compliance. Recent advances in surgical techniques, therapeutic approaches, and material sciences have produced exciting new therapies for ocular diseases. The development of new vehicles and drug formulations that require less patient compliance is also discussed, as are the routes of drug delivery for neuroprotection.

Original languageEnglish (US)
Pages (from-to)147-156
Number of pages10
JournalJournal of Glaucoma
Volume17
Issue number2
DOIs
StatePublished - Mar 1 2008

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Glaucoma
Drug Compounding
Patient Compliance
Pharmaceutical Preparations
Eye Diseases
Pharmacokinetics
Therapeutics
Neuroprotection

Keywords

  • Glaucoma drug delivery
  • Topical medications

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Barriers to glaucoma drug delivery. / Ghate, Deepta A; Edelhauser, Henry F.

In: Journal of Glaucoma, Vol. 17, No. 2, 01.03.2008, p. 147-156.

Research output: Contribution to journalReview article

Ghate, Deepta A ; Edelhauser, Henry F. / Barriers to glaucoma drug delivery. In: Journal of Glaucoma. 2008 ; Vol. 17, No. 2. pp. 147-156.
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