Baroreceptor reflex in heart failure.

Wei Wang, Guo Qing Zhu, Lie Gao, Wen Tan, Zhong Ming Qian

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Congestive heart failure is a syndrome that is usually initiated by a reduction in pump function of the heart, i.e. a decrease in cardiac output. Initially, a reduction in cardiac output leads to unloading of baroreceptor reflex that, in turn, increases heart rate through vago-sympathetic mechanisms and total peripheral resistance via an increase in sympathetic outflow to vascular beds. In this review we are thinking on how baroreceptor reflex plays a role in the abnormal control of the circulation in heart failure. This review and our recent studies suggest that: (1) baroreceptor reflex is blunted in heart failure; (2) central angiotensin II and reactive oxygen species play an important role in blunted baroreceptor reflex; (3) cardiac sympathetic afferent stimulation and chemoreceptor reflex inhibit baroreceptor reflex; and (4) exercise training normalizes abnormal reflexes in the heart failure state.

Original languageEnglish (US)
Pages (from-to)269-281
Number of pages13
JournalSheng li xue bao : [Acta physiologica Sinica]
Volume56
Issue number3
StatePublished - Jun 25 2004

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Baroreflex
Heart Failure
Cardiac Output
Abnormal Reflexes
Angiotensin II
Vascular Resistance
Blood Vessels
Reflex
Reactive Oxygen Species
Heart Rate
Exercise

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Wang, W., Zhu, G. Q., Gao, L., Tan, W., & Qian, Z. M. (2004). Baroreceptor reflex in heart failure. Sheng li xue bao : [Acta physiologica Sinica], 56(3), 269-281.

Baroreceptor reflex in heart failure. / Wang, Wei; Zhu, Guo Qing; Gao, Lie; Tan, Wen; Qian, Zhong Ming.

In: Sheng li xue bao : [Acta physiologica Sinica], Vol. 56, No. 3, 25.06.2004, p. 269-281.

Research output: Contribution to journalReview article

Wang, W, Zhu, GQ, Gao, L, Tan, W & Qian, ZM 2004, 'Baroreceptor reflex in heart failure.', Sheng li xue bao : [Acta physiologica Sinica], vol. 56, no. 3, pp. 269-281.
Wang W, Zhu GQ, Gao L, Tan W, Qian ZM. Baroreceptor reflex in heart failure. Sheng li xue bao : [Acta physiologica Sinica]. 2004 Jun 25;56(3):269-281.
Wang, Wei ; Zhu, Guo Qing ; Gao, Lie ; Tan, Wen ; Qian, Zhong Ming. / Baroreceptor reflex in heart failure. In: Sheng li xue bao : [Acta physiologica Sinica]. 2004 ; Vol. 56, No. 3. pp. 269-281.
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