BAR Domains and BAR Domain Superfamily Proteins

M. Sharma, Steven H Caplan

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The BIN-Amphiphysin-Rvs (BAR) domain is an evolutionarily conserved region found in over 750 proteins. BAR domain superfamily members dimerize to form a surface capable of membrane sensing and binding. Such membrane remodeling is essential for the organization and function of intracellular organelles, thus influencing important cellular events including endocytic and membrane trafficking, cell cycle, division, and migration. In this article, we examine the different subfamilies of BAR domain proteins and discuss how they exert their influence to shape membranes. We also focus on the roles of key BAR domain proteins and their roles in mediating actin assembly and intracellular transport and signaling.

Original languageEnglish (US)
Title of host publicationOrganizational Cell Biology
PublisherElsevier Inc.
Pages491-502
Number of pages12
Volume2
ISBN (Electronic)9780123944474
ISBN (Print)9780123947963
DOIs
StatePublished - Jan 1 2016

Fingerprint

Membranes
Organelles
Cell Division
Cell Movement
Actins
Cell Cycle
amphiphysin
Protein Domains
Proteins

Keywords

  • BAR domain
  • Clathrin-coated pits
  • Curvature-sensing
  • Cytoskeleton
  • Dimerization
  • Dynamin
  • Membrane curvature
  • Nucleation promoting factors
  • PHOX-domain
  • Pleckstrin homology domain

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Sharma, M., & Caplan, S. H. (2016). BAR Domains and BAR Domain Superfamily Proteins. In Organizational Cell Biology (Vol. 2, pp. 491-502). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-394447-4.20050-3

BAR Domains and BAR Domain Superfamily Proteins. / Sharma, M.; Caplan, Steven H.

Organizational Cell Biology. Vol. 2 Elsevier Inc., 2016. p. 491-502.

Research output: Chapter in Book/Report/Conference proceedingChapter

Sharma, M & Caplan, SH 2016, BAR Domains and BAR Domain Superfamily Proteins. in Organizational Cell Biology. vol. 2, Elsevier Inc., pp. 491-502. https://doi.org/10.1016/B978-0-12-394447-4.20050-3
Sharma M, Caplan SH. BAR Domains and BAR Domain Superfamily Proteins. In Organizational Cell Biology. Vol. 2. Elsevier Inc. 2016. p. 491-502 https://doi.org/10.1016/B978-0-12-394447-4.20050-3
Sharma, M. ; Caplan, Steven H. / BAR Domains and BAR Domain Superfamily Proteins. Organizational Cell Biology. Vol. 2 Elsevier Inc., 2016. pp. 491-502
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