Autotransplants in advanced non-Hodgkin lymphoma: Are they effective?

Antonella Surbone, James Olen Armitage, Robert Peter Gale

Research output: Contribution to journalArticle

Abstract

Recent data suggest that intensive therapy followed by a bone marrow autotransplant is effective in advanced intermediate and high-grade non-Hodgkin lymphoma (predominantly large-cell lymphoma). Twelve studies of autotransplants were analyzed to determine outcome. Results compared to data from 29 chemotherapy studies. Complete remission was reported in 53% of autotransplant recipients versus 17% of persons receiving chemotherapy. Two-year disease-free survival was 16 and 2%, respectively. It is uncertain whether these differences indicate superiority of autotransplants or reflect selection biases. Also unknown is whether similar results might not be obtained with similarly intensive treatment without an autotransplant.

Original languageEnglish (US)
Pages (from-to)343-347
Number of pages5
JournalCell Transplantation
Volume1
Issue number5
DOIs
StatePublished - 1992

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Chemotherapy
Autografts
Non-Hodgkin's Lymphoma
Bone
Drug Therapy
Selection Bias
Disease-Free Survival
Lymphoma
Bone Marrow
Therapeutics

Keywords

  • Autotransplant
  • Bone marrow
  • Chemotherapy
  • Lymphoma

ASJC Scopus subject areas

  • Biomedical Engineering
  • Cell Biology
  • Transplantation

Cite this

Autotransplants in advanced non-Hodgkin lymphoma : Are they effective? / Surbone, Antonella; Armitage, James Olen; Gale, Robert Peter.

In: Cell Transplantation, Vol. 1, No. 5, 1992, p. 343-347.

Research output: Contribution to journalArticle

Surbone, Antonella ; Armitage, James Olen ; Gale, Robert Peter. / Autotransplants in advanced non-Hodgkin lymphoma : Are they effective?. In: Cell Transplantation. 1992 ; Vol. 1, No. 5. pp. 343-347.
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