Autotransplantatsiia pri limfomakh

iavliaetsia li ona éffektivnoǐ.

Translated title of the contribution: Autotransplantation in lymphomas: is it effective?

A. Surbone, James Olen Armitage, R. P. Gale

Research output: Contribution to journalReview article

Abstract

Recent data suggest that intensive chemotherapy, with or without radiation, followed by a bone marrow autotransplant is effective in advanced intermediate and high-grade non-Hodgkin lymphoma (predominantly large-cell lymphoma). We analyzed 12 studies of the autotransplants to determine outcomes. The results were compared to data from 29 chemotherapy studies. Complete remissions were reported in 53 percent of autotransplant recipients versus 17 percent of persons receiving chemotherapy. Two-year disease-free survival was 16 percent and 3 percent, respectively. It is uncertain whether these differences reflect subject selection or time to treatment (time censoring) biases in the autotransplant cohort. A randomized trial is needed to determine if autotransplants are superior to chemotherapy. Also unknown is whether similar results might not be obtained with higher doses of chemotherapy without an autotransplant.

Original languageRussian
Pages (from-to)3-6
Number of pages4
JournalGematologiya i Transfusiologiya
Volume37
Issue number7-8
StatePublished - Jul 1 1992

Fingerprint

Autologous Transplantation
Autografts
Lymphoma
Drug Therapy
Non-Hodgkin's Lymphoma
Patient Selection
Disease-Free Survival
Bone Marrow
Radiation

ASJC Scopus subject areas

  • Hematology

Cite this

Autotransplantatsiia pri limfomakh : iavliaetsia li ona éffektivnoǐ. / Surbone, A.; Armitage, James Olen; Gale, R. P.

In: Gematologiya i Transfusiologiya, Vol. 37, No. 7-8, 01.07.1992, p. 3-6.

Research output: Contribution to journalReview article

@article{0b02f2a6e53148548e61188e0773dede,
title = "Autotransplantatsiia pri limfomakh: iavliaetsia li ona {\'e}ffektivnoǐ.",
abstract = "Recent data suggest that intensive chemotherapy, with or without radiation, followed by a bone marrow autotransplant is effective in advanced intermediate and high-grade non-Hodgkin lymphoma (predominantly large-cell lymphoma). We analyzed 12 studies of the autotransplants to determine outcomes. The results were compared to data from 29 chemotherapy studies. Complete remissions were reported in 53 percent of autotransplant recipients versus 17 percent of persons receiving chemotherapy. Two-year disease-free survival was 16 percent and 3 percent, respectively. It is uncertain whether these differences reflect subject selection or time to treatment (time censoring) biases in the autotransplant cohort. A randomized trial is needed to determine if autotransplants are superior to chemotherapy. Also unknown is whether similar results might not be obtained with higher doses of chemotherapy without an autotransplant.",
author = "A. Surbone and Armitage, {James Olen} and Gale, {R. P.}",
year = "1992",
month = "7",
day = "1",
language = "Russian",
volume = "37",
pages = "3--6",
journal = "Gematologiya i Transfuziologiya",
issn = "0234-5730",
publisher = "Izdatel'stvo Meditsina",
number = "7-8",

}

TY - JOUR

T1 - Autotransplantatsiia pri limfomakh

T2 - iavliaetsia li ona éffektivnoǐ.

AU - Surbone, A.

AU - Armitage, James Olen

AU - Gale, R. P.

PY - 1992/7/1

Y1 - 1992/7/1

N2 - Recent data suggest that intensive chemotherapy, with or without radiation, followed by a bone marrow autotransplant is effective in advanced intermediate and high-grade non-Hodgkin lymphoma (predominantly large-cell lymphoma). We analyzed 12 studies of the autotransplants to determine outcomes. The results were compared to data from 29 chemotherapy studies. Complete remissions were reported in 53 percent of autotransplant recipients versus 17 percent of persons receiving chemotherapy. Two-year disease-free survival was 16 percent and 3 percent, respectively. It is uncertain whether these differences reflect subject selection or time to treatment (time censoring) biases in the autotransplant cohort. A randomized trial is needed to determine if autotransplants are superior to chemotherapy. Also unknown is whether similar results might not be obtained with higher doses of chemotherapy without an autotransplant.

AB - Recent data suggest that intensive chemotherapy, with or without radiation, followed by a bone marrow autotransplant is effective in advanced intermediate and high-grade non-Hodgkin lymphoma (predominantly large-cell lymphoma). We analyzed 12 studies of the autotransplants to determine outcomes. The results were compared to data from 29 chemotherapy studies. Complete remissions were reported in 53 percent of autotransplant recipients versus 17 percent of persons receiving chemotherapy. Two-year disease-free survival was 16 percent and 3 percent, respectively. It is uncertain whether these differences reflect subject selection or time to treatment (time censoring) biases in the autotransplant cohort. A randomized trial is needed to determine if autotransplants are superior to chemotherapy. Also unknown is whether similar results might not be obtained with higher doses of chemotherapy without an autotransplant.

UR - http://www.scopus.com/inward/record.url?scp=0026884291&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026884291&partnerID=8YFLogxK

M3 - Review article

VL - 37

SP - 3

EP - 6

JO - Gematologiya i Transfuziologiya

JF - Gematologiya i Transfuziologiya

SN - 0234-5730

IS - 7-8

ER -