Autosomal dominant branchio-oto-renal syndrome - localization of a disease gene to chromosome 8q by linkage in a dutch family

Shrawan Kumar, William J. Kimberling, Judy B. Kenyon, Richard J.H. Smith, Henri A.M. Marres, Cor W.R.J. Cremers

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Abstract

Branchio-oto-renal syndrome (BOR) is an autosomal dominant disorder with variable clinical manifestations affecting branchial, renal and auditory development. Varying clinical expression of the disease between different families suggests that multiple loci may be involved. However, the possibility of genetic heterogeneity as the cause of clinical variability cannot be resolved until the gene(s) causing BOR syndrome are mapped. DNA from four generations of a family with autosomal dominant BOR syndrome have been typed with a series of genetic markers on the long arm of chromosome 8. Using two point linkage analysis, a significant lod score of Z = 4.0 at θ = 0.05 was obtained with the D8S165 microsatellite marker. Multipoint analyses with 8q markers place the gene for BOR between the markers D8S87 and D8S165.

Original languageEnglish (US)
Pages (from-to)491-495
Number of pages5
JournalHuman Molecular Genetics
Volume1
Issue number7
DOIs
Publication statusPublished - Oct 1 1992

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ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Cite this

Kumar, S., Kimberling, W. J., Kenyon, J. B., Smith, R. J. H., Marres, H. A. M., & Cremers, C. W. R. J. (1992). Autosomal dominant branchio-oto-renal syndrome - localization of a disease gene to chromosome 8q by linkage in a dutch family. Human Molecular Genetics, 1(7), 491-495. https://doi.org/10.1093/hmg/1.7.491