Autophagy and p62 in cardiac protein quality control

Huabo Su, Xuejun Wang

Research output: Contribution to journalShort survey

8 Citations (Scopus)

Abstract

This is an addendum to a recent report which demonstrates for the first time that autophagic flux is increased in the heart of a well-established mouse model of cardiac proteinopathy and p62 is transcriptionally upregulated in cardiomyocytes and hearts overexpressing human cardiomyopathy-linked misfolded proteins. The p62 plays a critical and protective role in aggresome formation and autophagic activation in cardiomyocytes overexpressing misfolded proteins.

Original languageEnglish (US)
Pages (from-to)1382-1383
Number of pages2
JournalAutophagy
Volume7
Issue number11
DOIs
StatePublished - Jan 1 2011

Fingerprint

Autophagy
Cardiac Myocytes
Quality Control
Cardiomyopathies
Proteins

Keywords

  • Autophagy
  • Cardiomyocytes
  • Desmin-related cardiomyopathy
  • Protein aggregation
  • p62

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Autophagy and p62 in cardiac protein quality control. / Su, Huabo; Wang, Xuejun.

In: Autophagy, Vol. 7, No. 11, 01.01.2011, p. 1382-1383.

Research output: Contribution to journalShort survey

Su, Huabo ; Wang, Xuejun. / Autophagy and p62 in cardiac protein quality control. In: Autophagy. 2011 ; Vol. 7, No. 11. pp. 1382-1383.
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