Autologous transplantation for diffuse aggressive Non-Hodgkin lymphoma in first relapse or second remission

Julie Marie Vose, Douglas J. Rizzo, Jing Tao-Wu, James Olen Armitage, Asad Bashey, Linda J. Burns, Neal Paul Christiansen, Cesar O. Freytes, Robert Peter Gale, John Gibson, Sergio A. Giralt, Roger H. Herzig, Charles F. Lemaistre, Philip L. McCarthy, Stephen D. Nimer, Finn B. Petersen, David P. Schenkein, Peter H. Wiernik, Joseph M. Wiley, Fausto R. Loberiza & 3 others Hillard M. Lazarus, Koen van Biesen, Mary M. Horowitz

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Abstract

We evaluated the results of high-dose chemotherapy and autologous hematopoietic stem cell transplantation in patients with diffuse aggressive non-Hodgkin lymphoma (NHL) in first relapse (Rel 1) or second complete remission (CR 2). Data were evaluated from the Autologous Blood and Marrow Transplant Registry on 429 patients with diffuse aggressive NHL who underwent transplantation in Rel 1 or CR 2. Transplantations were performed between 1989 and 1996 and were reported to the Autologous Blood and Marrow Transplant Registry by 93 centers in North and South America. The probability of 3-year survival was 44% (95% confidence interval [CI], 33%-55%). The probability at 3 years of progression-free survival was 31% (95% CI, 27%-36%). Patients who underwent transplantation in CR 2 had a 3-year probability of progression-free survival of 38% (95% CI, 30%-46%) compared with 28% (95% CI, 22%-33%) for those who were not in remission at the time of transplantation (P<.001). In multivariate analysis, chemotherapy resistance, increased lactic dehydrogenase at diagnosis, an interval of <12 months from diagnosis to relapse, age ≥40 years, and use of myeloid growth factors to accelerate posttransplantation bone marrow recovery were adverse predictors of survival. High-dose chemotherapy and autologous hematopoietic stem cell transplantation for patients with diffuse aggressive NHL in CR 2 or Rel 1 resulted in better outcome for patients with chemotherapy-sensitive disease, longer relapse-free intervals, and age <40 years. Exposure to myeloid growth factors to accelerate recovery for recipients of bone marrow grafts may increase the risk of disease progression or death.

Original languageEnglish (US)
Pages (from-to)116-127
Number of pages12
JournalBiology of Blood and Marrow Transplantation
Volume10
Issue number2
DOIs
StatePublished - Feb 1 2004

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Autologous Transplantation
Non-Hodgkin's Lymphoma
Recurrence
Transplantation
Bone Marrow
Confidence Intervals
Drug Therapy
Hematopoietic Stem Cell Transplantation
Transplants
Disease-Free Survival
Registries
Intercellular Signaling Peptides and Proteins
Survival
South America
North America
Disease Progression
Oxidoreductases
Milk
Multivariate Analysis

Keywords

  • Hematopoietic stem cell transplantation
  • High-dose chemotherapy
  • Non-Hodgkin lymphoma

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Autologous transplantation for diffuse aggressive Non-Hodgkin lymphoma in first relapse or second remission. / Vose, Julie Marie; Rizzo, Douglas J.; Tao-Wu, Jing; Armitage, James Olen; Bashey, Asad; Burns, Linda J.; Christiansen, Neal Paul; Freytes, Cesar O.; Gale, Robert Peter; Gibson, John; Giralt, Sergio A.; Herzig, Roger H.; Lemaistre, Charles F.; McCarthy, Philip L.; Nimer, Stephen D.; Petersen, Finn B.; Schenkein, David P.; Wiernik, Peter H.; Wiley, Joseph M.; Loberiza, Fausto R.; Lazarus, Hillard M.; van Biesen, Koen; Horowitz, Mary M.

In: Biology of Blood and Marrow Transplantation, Vol. 10, No. 2, 01.02.2004, p. 116-127.

Research output: Contribution to journalArticle

Vose, JM, Rizzo, DJ, Tao-Wu, J, Armitage, JO, Bashey, A, Burns, LJ, Christiansen, NP, Freytes, CO, Gale, RP, Gibson, J, Giralt, SA, Herzig, RH, Lemaistre, CF, McCarthy, PL, Nimer, SD, Petersen, FB, Schenkein, DP, Wiernik, PH, Wiley, JM, Loberiza, FR, Lazarus, HM, van Biesen, K & Horowitz, MM 2004, 'Autologous transplantation for diffuse aggressive Non-Hodgkin lymphoma in first relapse or second remission', Biology of Blood and Marrow Transplantation, vol. 10, no. 2, pp. 116-127. https://doi.org/10.1016/j.bbmt.2003.09.015
Vose, Julie Marie ; Rizzo, Douglas J. ; Tao-Wu, Jing ; Armitage, James Olen ; Bashey, Asad ; Burns, Linda J. ; Christiansen, Neal Paul ; Freytes, Cesar O. ; Gale, Robert Peter ; Gibson, John ; Giralt, Sergio A. ; Herzig, Roger H. ; Lemaistre, Charles F. ; McCarthy, Philip L. ; Nimer, Stephen D. ; Petersen, Finn B. ; Schenkein, David P. ; Wiernik, Peter H. ; Wiley, Joseph M. ; Loberiza, Fausto R. ; Lazarus, Hillard M. ; van Biesen, Koen ; Horowitz, Mary M. / Autologous transplantation for diffuse aggressive Non-Hodgkin lymphoma in first relapse or second remission. In: Biology of Blood and Marrow Transplantation. 2004 ; Vol. 10, No. 2. pp. 116-127.
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AU - Gale, Robert Peter

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