Autologous platelet gel in coronary artery bypass grafting

Effects on surgical wound healing

See N. Vang, Chad P. Brady, Kevin A. Christensen, Keith R. Allen, John E. Anderson, Jack R. Isler, David W. Holt, Lynette M Smith

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Stimulating the body's natural healing at the cellular level can be achieved through the application of growth factors located within platelets. Once combined with a mixture of calcium and thrombin, this substance, now referred to as autologous platelet gel (APG), can be applied to surgical wound sites for patients undergoing cardiac surgery. The purpose of this study was to examine the effects of APG on surgical site infection, post-operative pain, blood loss, and bruising. After 30 mL platelet-rich plasma (PRP) was processed, 10 mL PRP was distributed on the sternum after re-approximation and 7 mL PRP before skin closure. Ten milliliters PRP was used on the endoscopic leg harvest (EVH) site. The remaining 3 mL was sent to the laboratory for hematologic testing. Both the control (CTR) and treatment (TRT) groups were well matched, with the exception of ejection fraction and pre-operative platelet count, which was significantly higher in the TRT group. Average platelet count yield was 4.2 ± 0.5 × 103/mcL, white blood count (WBC) yielded 1.9 ± 0.7 × 103/mcL, and fibrinogen yielded 1.2 ± 0.2 mg/dL above baseline. There were no deep or superficial sternal infections. However, one patient from each group did experience a leg infection at the EVH site, which occurred after hospital discharge. More patients in the TRT group experienced less pain on postoperative day (POD) 1 and at the post-operative office follow-up. Blood loss and bruising was less in the TRT group on POD 2; however, there was no statistical significance. The application of APG seems to confer beneficial effects on pain, blood loss, and bruising. However, further studies with a greater sample size are needed to power significant differences.

Original languageEnglish (US)
Pages (from-to)31-38
Number of pages8
JournalJournal of Extra-Corporeal Technology
Volume39
Issue number1
StatePublished - Mar 1 2007

Fingerprint

Platelet-Rich Plasma
Coronary Artery Bypass
Wound Healing
Blood Platelets
Gels
Platelet Count
Leg
Surgical Wound Infection
Pain
Sternum
Therapeutics
Postoperative Pain
Infection
Thrombin
Sample Size
Fibrinogen
Thoracic Surgery
Intercellular Signaling Peptides and Proteins
Calcium
Control Groups

Keywords

  • Autologous platelet gel
  • Bruising
  • Growth factors
  • Nociceptors
  • Pain
  • Surgical site infection

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Health Professions (miscellaneous)
  • Cardiology and Cardiovascular Medicine

Cite this

Vang, S. N., Brady, C. P., Christensen, K. A., Allen, K. R., Anderson, J. E., Isler, J. R., ... Smith, L. M. (2007). Autologous platelet gel in coronary artery bypass grafting: Effects on surgical wound healing. Journal of Extra-Corporeal Technology, 39(1), 31-38.

Autologous platelet gel in coronary artery bypass grafting : Effects on surgical wound healing. / Vang, See N.; Brady, Chad P.; Christensen, Kevin A.; Allen, Keith R.; Anderson, John E.; Isler, Jack R.; Holt, David W.; Smith, Lynette M.

In: Journal of Extra-Corporeal Technology, Vol. 39, No. 1, 01.03.2007, p. 31-38.

Research output: Contribution to journalArticle

Vang, SN, Brady, CP, Christensen, KA, Allen, KR, Anderson, JE, Isler, JR, Holt, DW & Smith, LM 2007, 'Autologous platelet gel in coronary artery bypass grafting: Effects on surgical wound healing', Journal of Extra-Corporeal Technology, vol. 39, no. 1, pp. 31-38.
Vang SN, Brady CP, Christensen KA, Allen KR, Anderson JE, Isler JR et al. Autologous platelet gel in coronary artery bypass grafting: Effects on surgical wound healing. Journal of Extra-Corporeal Technology. 2007 Mar 1;39(1):31-38.
Vang, See N. ; Brady, Chad P. ; Christensen, Kevin A. ; Allen, Keith R. ; Anderson, John E. ; Isler, Jack R. ; Holt, David W. ; Smith, Lynette M. / Autologous platelet gel in coronary artery bypass grafting : Effects on surgical wound healing. In: Journal of Extra-Corporeal Technology. 2007 ; Vol. 39, No. 1. pp. 31-38.
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