Autoimmunity of the lung and oral mucosa in a multisystem inflammatory disease: The spark that lights the fire in rheumatoid arthritis?

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

There is a growing body of evidence to suggest that autoimmunity in patients with rheumatoid arthritis (RA) is initiated outside the joint. This is supported by the observation that circulating autoantibodies, including both rheumatoid factor and anti-citrullinated protein antibody, can be detected in many subjects years before the development of initial joint symptoms leading to an RA diagnosis. Of the potential extra-articular sites implicated in disease initiation, mucosal tissues have garnered increasing attention. Several lines of investigation have separately implicated mucosal tissues from varying anatomic locations as possible initiating sites for RA, including those from the lung and oral cavity. In this review we summarize recent reports incriminating these mucosal tissues as the initial site of autoantibody generation and inflammation in patients with RA.

Original languageEnglish (US)
Pages (from-to)28-34
Number of pages7
JournalJournal of Allergy and Clinical Immunology
Volume137
Issue number1
DOIs
StatePublished - Jan 1 2016

Fingerprint

Mouth Mucosa
Autoimmunity
Rheumatoid Arthritis
Light
Lung
Mucous Membrane
Joints
Autoantibodies
Rheumatoid Factor
Mouth
Inflammation
Antibodies
Proteins

Keywords

  • Rheumatoid arthritis
  • anti-citrullinated protein antibody
  • autoantibody
  • mucosal inflammation
  • rheumatoid factor

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

@article{9ade16e776234ece9a5392201c4aa668,
title = "Autoimmunity of the lung and oral mucosa in a multisystem inflammatory disease: The spark that lights the fire in rheumatoid arthritis?",
abstract = "There is a growing body of evidence to suggest that autoimmunity in patients with rheumatoid arthritis (RA) is initiated outside the joint. This is supported by the observation that circulating autoantibodies, including both rheumatoid factor and anti-citrullinated protein antibody, can be detected in many subjects years before the development of initial joint symptoms leading to an RA diagnosis. Of the potential extra-articular sites implicated in disease initiation, mucosal tissues have garnered increasing attention. Several lines of investigation have separately implicated mucosal tissues from varying anatomic locations as possible initiating sites for RA, including those from the lung and oral cavity. In this review we summarize recent reports incriminating these mucosal tissues as the initial site of autoantibody generation and inflammation in patients with RA.",
keywords = "Rheumatoid arthritis, anti-citrullinated protein antibody, autoantibody, mucosal inflammation, rheumatoid factor",
author = "Mikuls, {Ted R} and Payne, {Jeffrey B} and Deane, {Kevin D.} and Thiele, {Geoffrey Milton}",
year = "2016",
month = "1",
day = "1",
doi = "10.1016/j.jaci.2015.10.024",
language = "English (US)",
volume = "137",
pages = "28--34",
journal = "Journal of Allergy and Clinical Immunology",
issn = "0091-6749",
publisher = "Mosby Inc.",
number = "1",

}

TY - JOUR

T1 - Autoimmunity of the lung and oral mucosa in a multisystem inflammatory disease

T2 - The spark that lights the fire in rheumatoid arthritis?

AU - Mikuls, Ted R

AU - Payne, Jeffrey B

AU - Deane, Kevin D.

AU - Thiele, Geoffrey Milton

PY - 2016/1/1

Y1 - 2016/1/1

N2 - There is a growing body of evidence to suggest that autoimmunity in patients with rheumatoid arthritis (RA) is initiated outside the joint. This is supported by the observation that circulating autoantibodies, including both rheumatoid factor and anti-citrullinated protein antibody, can be detected in many subjects years before the development of initial joint symptoms leading to an RA diagnosis. Of the potential extra-articular sites implicated in disease initiation, mucosal tissues have garnered increasing attention. Several lines of investigation have separately implicated mucosal tissues from varying anatomic locations as possible initiating sites for RA, including those from the lung and oral cavity. In this review we summarize recent reports incriminating these mucosal tissues as the initial site of autoantibody generation and inflammation in patients with RA.

AB - There is a growing body of evidence to suggest that autoimmunity in patients with rheumatoid arthritis (RA) is initiated outside the joint. This is supported by the observation that circulating autoantibodies, including both rheumatoid factor and anti-citrullinated protein antibody, can be detected in many subjects years before the development of initial joint symptoms leading to an RA diagnosis. Of the potential extra-articular sites implicated in disease initiation, mucosal tissues have garnered increasing attention. Several lines of investigation have separately implicated mucosal tissues from varying anatomic locations as possible initiating sites for RA, including those from the lung and oral cavity. In this review we summarize recent reports incriminating these mucosal tissues as the initial site of autoantibody generation and inflammation in patients with RA.

KW - Rheumatoid arthritis

KW - anti-citrullinated protein antibody

KW - autoantibody

KW - mucosal inflammation

KW - rheumatoid factor

UR - http://www.scopus.com/inward/record.url?scp=84953449570&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84953449570&partnerID=8YFLogxK

U2 - 10.1016/j.jaci.2015.10.024

DO - 10.1016/j.jaci.2015.10.024

M3 - Article

C2 - 26768760

AN - SCOPUS:84953449570

VL - 137

SP - 28

EP - 34

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

SN - 0091-6749

IS - 1

ER -