Autoimmunity in picornavirus infections

Chandirasegaran Massilamany, Andreas Koenig, N R Jayagopala Reddy, Sally Huber, Iwona Buskiewicz

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

Enteroviruses are small, non-enveloped, positive-sense single-strand RNA viruses, and are ubiquitously found throughout the world. These viruses usually cause asymptomatic or mild febrile illnesses, but have a propensity to induce severe diseases including type 1 diabetes and pancreatitis, paralysis and neuroinflammatory disease, myocarditis, or hepatitis. This pathogenicity may result from induction of autoimmunity to organ-specific antigens. While enterovirus-triggered autoimmunity can arise from multiple mechanisms including antigenic mimicry and release of sequestered antigens, the recent demonstration of T cells expressing dual T cell receptors arising as a natural consequence of Theiler's virus infection is the first demonstration of this autoimmune mechanism.

Original languageEnglish (US)
Pages (from-to)8-14
Number of pages7
JournalCurrent Opinion in Virology
Volume16
DOIs
StatePublished - Feb 1 2016

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Picornaviridae Infections
Enterovirus
Autoimmunity
Theilovirus
Molecular Mimicry
Antigens
RNA Viruses
Myocarditis
Virus Diseases
T-Cell Antigen Receptor
Type 1 Diabetes Mellitus
Paralysis
Pancreatitis
Hepatitis
Virulence
Fever
Viruses
T-Lymphocytes

ASJC Scopus subject areas

  • Virology

Cite this

Autoimmunity in picornavirus infections. / Massilamany, Chandirasegaran; Koenig, Andreas; Reddy, N R Jayagopala; Huber, Sally; Buskiewicz, Iwona.

In: Current Opinion in Virology, Vol. 16, 01.02.2016, p. 8-14.

Research output: Contribution to journalReview article

Massilamany, C, Koenig, A, Reddy, NRJ, Huber, S & Buskiewicz, I 2016, 'Autoimmunity in picornavirus infections', Current Opinion in Virology, vol. 16, pp. 8-14. https://doi.org/10.1016/j.coviro.2015.10.004
Massilamany, Chandirasegaran ; Koenig, Andreas ; Reddy, N R Jayagopala ; Huber, Sally ; Buskiewicz, Iwona. / Autoimmunity in picornavirus infections. In: Current Opinion in Virology. 2016 ; Vol. 16. pp. 8-14.
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