Autoimmune neutropenia in multiple myeloma and the role of clonal t-cell expansion: Evidence of cross-talk between B-cell and T-cell lineages?

Madan Raj Aryal, Vijaya Raj Bhatt, Pavankumar Tandra, Jairam Krishnamurthy, Ji Yuan, Timothy C. Greiner, Mojtaba Akhtari

Research output: Contribution to journalArticle

2 Scopus citations


Autoimmune neutropenia (AIN), characterized by an absolute neutrophil count below 1500 cells/mL in the presence of autoantibodies directed against neutrophil antigens, can be secondary to a variety of underlying diseases, such as connective tissue diseases, infections, and malignancies. However, it has not been reported in association with multiple myeloma (MM). We report a case of AIN in a patient with MM who also had a population of small lymphocytes with T-cell receptor gamma chain gene rearrangements. We also review other autoimmune manifestations of MM, the role of T-cell receptor gene rearrangement in AIN, and the implications of AIN in the management of MM. AIN can develop as a consequence of MM, and it is likely underdiagnosed because of the diagnostic difficulties. AIN can increase the risk of recurrent or serious infections in patients undergoing chemotherapy.

Original languageEnglish (US)
Pages (from-to)e19-e23
JournalClinical Lymphoma, Myeloma and Leukemia
Issue number1
StatePublished - Feb 1 2014



  • Anti-neutrophil antibody
  • Filgrastim
  • T-cell receptor gene rearrangement
  • T-lymphocyte

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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