Autoimmune neutropenia in multiple myeloma and the role of clonal t-cell expansion: Evidence of cross-talk between B-cell and T-cell lineages?

Madan Raj Aryal, Vijaya R Bhatt, Pavankumar Tandra, Jairam Krishnamurthy, Ji Yuan, Timothy Charles Greiner, Mojtaba Akhtari

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Autoimmune neutropenia (AIN), characterized by an absolute neutrophil count below 1500 cells/mL in the presence of autoantibodies directed against neutrophil antigens, can be secondary to a variety of underlying diseases, such as connective tissue diseases, infections, and malignancies. However, it has not been reported in association with multiple myeloma (MM). We report a case of AIN in a patient with MM who also had a population of small lymphocytes with T-cell receptor gamma chain gene rearrangements. We also review other autoimmune manifestations of MM, the role of T-cell receptor gene rearrangement in AIN, and the implications of AIN in the management of MM. AIN can develop as a consequence of MM, and it is likely underdiagnosed because of the diagnostic difficulties. AIN can increase the risk of recurrent or serious infections in patients undergoing chemotherapy.

Original languageEnglish (US)
Pages (from-to)e19-e23
JournalClinical Lymphoma, Myeloma and Leukemia
Volume14
Issue number1
DOIs
StatePublished - Feb 1 2014

Fingerprint

Cell Lineage
Neutropenia
Multiple Myeloma
B-Lymphocytes
T-Lymphocytes
gamma-Chain T-Cell Antigen Receptor Gene Rearrangement
Neutrophils
T-Cell Receptor gamma Genes
T-Lymphocyte Gene Rearrangement
T-Cell Receptor Genes
Connective Tissue Diseases
Infection
Autoantibodies
Lymphocytes
Antigens
Drug Therapy
Population
Neoplasms

Keywords

  • Anti-neutrophil antibody
  • Filgrastim
  • T-cell receptor gene rearrangement
  • T-lymphocyte

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Autoimmune neutropenia in multiple myeloma and the role of clonal t-cell expansion : Evidence of cross-talk between B-cell and T-cell lineages? / Aryal, Madan Raj; Bhatt, Vijaya R; Tandra, Pavankumar; Krishnamurthy, Jairam; Yuan, Ji; Greiner, Timothy Charles; Akhtari, Mojtaba.

In: Clinical Lymphoma, Myeloma and Leukemia, Vol. 14, No. 1, 01.02.2014, p. e19-e23.

Research output: Contribution to journalArticle

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