Autoantibodies against β-crystallins induce lens epithelial cell damage and cataract formation in mice

D. P. Singh, S. C. Guru, T. Kikuchi, T. Abe, T. Shinohara

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

One-year-old B6C3/f mice, injected with β-crystallins emulsified with CFA, developed lens epithelial cell damage. Both serum transfer and mAb transfer studies clearly established that the autoimmune insult is induced by humoral immunity. Older mice were more susceptible to autoimmune insult than younger animals. Lens epithelial cell damage invariably proceeded to cortical and posterior subcapsular cataract formation. This mouse model of experimental autoimmune cataract formation will facilitate the exploration of the relation between immune phenomena and human age-related cataract.

Original languageEnglish (US)
Pages (from-to)993-999
Number of pages7
JournalJournal of Immunology
Volume155
Issue number2
Publication statusPublished - Jan 1 1995

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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