Auditory Brainstem Responses During Systemic Infusion of Lidocaine

Eric Javel, Daniel F. Mouney, JoAnn D McGee, Edward J Walsh

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Auditory brainstem-evoked responses (ABR) to clicks were recorded in unanesthetized restrained cats before, during, and after systemic intravenous infusion of lidocaine hydrochloride. The drug was infused continuously at varying rates. Lidocaine's major effect on ABR was to lengthen latent periods to all waveform peaks in proportion with the infusion rate. The effect on latent periods was cumulative throughout the auditory brainstem, ie, all interpeak time intervals increased. Increases in ABR latencies were not due to reductions in effective stimulus intensity because lidocaine did not reduce ABR component amplitudes or increase thresholds. The effects of the drug were reversible. The data are consistent with the notion that lidocaine, directly or indirectly, works throughout the auditory brainstem to increase axonal and synaptic conduction times.

Original languageEnglish (US)
Pages (from-to)71-76
Number of pages6
JournalArchives of Otolaryngology
Volume108
Issue number2
DOIs
StatePublished - Jan 1 1982

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Brain Stem Auditory Evoked Potentials
Lidocaine
Brain Stem
Intravenous Infusions
Pharmaceutical Preparations
Reaction Time
Cats

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Auditory Brainstem Responses During Systemic Infusion of Lidocaine. / Javel, Eric; Mouney, Daniel F.; McGee, JoAnn D; Walsh, Edward J.

In: Archives of Otolaryngology, Vol. 108, No. 2, 01.01.1982, p. 71-76.

Research output: Contribution to journalArticle

Javel, Eric ; Mouney, Daniel F. ; McGee, JoAnn D ; Walsh, Edward J. / Auditory Brainstem Responses During Systemic Infusion of Lidocaine. In: Archives of Otolaryngology. 1982 ; Vol. 108, No. 2. pp. 71-76.
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