Atypical presentation of primary central nervous system non-hodgkin lymphoma in immunocompetent young adults

Joseph T. Cheatle, Michele R Aizenberg Ansari, Jeffrey S. Weinberg, Daniel L Surdell

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Objective: Primary central nervous system non-Hodgkin lymphoma (PCNSL) is a malignant lymphoma limited to the cranial-spinal axis in the absence of systemic lymphoma. Historically, PCNSL accounts for fewer than 5% of all cases of primary intracranial neoplasms. PCNSL is rare in immunocompetent young adults. Although the prognosis for PCNSL is poor, approximately 20%-30% percent of cases achieve a cure. Methods: We report two cases of PCNSL originating in the ventricle in otherwise healthy immunocompetent young adults. Results: A 27-year-old man presented with 10 days of nausea, vomiting, and headache and was found to have a large intraventricular mass emanating from the choroid plexus with resultant hydrocephalus. He underwent placement of external ventricular drain and systemic and intrathecal chemotherapy for cytologically proven PCNSL. A 31-year-old pregnant woman presented with headaches, vision difficulties, and ataxia and was found to have a septum pellucidum mass. She underwent craniotomy and subtotal resection of the mass with subsequent systemic therapy and whole brain radiation for treatment of PCNSL. Conclusions: To our knowledge, this is the first report of primary CNS lymphoma of the choroid plexus and septum pellucidum in otherwise healthy, immunocompetent young adults.

Original languageEnglish (US)
Pages (from-to)593.e9-593.e13
JournalWorld Neurosurgery
Volume79
Issue number3-4
DOIs
StatePublished - Jan 1 2013

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Non-Hodgkin's Lymphoma
Young Adult
Central Nervous System
Septum Pellucidum
Lymphoma
Choroid Plexus
Headache
Craniotomy
Ataxia
Hydrocephalus
Brain Neoplasms
Nausea
Vomiting
Pregnant Women
Radiation
Drug Therapy
Brain
Therapeutics

Keywords

  • CNS lymphoma
  • Immunocompetent
  • Intraventricular
  • Primary choroid plexus
  • Septum pellucidum

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Atypical presentation of primary central nervous system non-hodgkin lymphoma in immunocompetent young adults. / Cheatle, Joseph T.; Aizenberg Ansari, Michele R; Weinberg, Jeffrey S.; Surdell, Daniel L.

In: World Neurosurgery, Vol. 79, No. 3-4, 01.01.2013, p. 593.e9-593.e13.

Research output: Contribution to journalReview article

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abstract = "Objective: Primary central nervous system non-Hodgkin lymphoma (PCNSL) is a malignant lymphoma limited to the cranial-spinal axis in the absence of systemic lymphoma. Historically, PCNSL accounts for fewer than 5{\%} of all cases of primary intracranial neoplasms. PCNSL is rare in immunocompetent young adults. Although the prognosis for PCNSL is poor, approximately 20{\%}-30{\%} percent of cases achieve a cure. Methods: We report two cases of PCNSL originating in the ventricle in otherwise healthy immunocompetent young adults. Results: A 27-year-old man presented with 10 days of nausea, vomiting, and headache and was found to have a large intraventricular mass emanating from the choroid plexus with resultant hydrocephalus. He underwent placement of external ventricular drain and systemic and intrathecal chemotherapy for cytologically proven PCNSL. A 31-year-old pregnant woman presented with headaches, vision difficulties, and ataxia and was found to have a septum pellucidum mass. She underwent craniotomy and subtotal resection of the mass with subsequent systemic therapy and whole brain radiation for treatment of PCNSL. Conclusions: To our knowledge, this is the first report of primary CNS lymphoma of the choroid plexus and septum pellucidum in otherwise healthy, immunocompetent young adults.",
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AB - Objective: Primary central nervous system non-Hodgkin lymphoma (PCNSL) is a malignant lymphoma limited to the cranial-spinal axis in the absence of systemic lymphoma. Historically, PCNSL accounts for fewer than 5% of all cases of primary intracranial neoplasms. PCNSL is rare in immunocompetent young adults. Although the prognosis for PCNSL is poor, approximately 20%-30% percent of cases achieve a cure. Methods: We report two cases of PCNSL originating in the ventricle in otherwise healthy immunocompetent young adults. Results: A 27-year-old man presented with 10 days of nausea, vomiting, and headache and was found to have a large intraventricular mass emanating from the choroid plexus with resultant hydrocephalus. He underwent placement of external ventricular drain and systemic and intrathecal chemotherapy for cytologically proven PCNSL. A 31-year-old pregnant woman presented with headaches, vision difficulties, and ataxia and was found to have a septum pellucidum mass. She underwent craniotomy and subtotal resection of the mass with subsequent systemic therapy and whole brain radiation for treatment of PCNSL. Conclusions: To our knowledge, this is the first report of primary CNS lymphoma of the choroid plexus and septum pellucidum in otherwise healthy, immunocompetent young adults.

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