Attentional control abnormalities in posttraumatic stress disorder: Functional, behavioral, and structural correlates

Negar Fani, Tricia Z. King, Cherita Clendinen, Raven A. Hardy, Sindhuja Surapaneni, James R. Blair, Stuart F. White, Abigail Powers, Tim D. Ely, Tanja Jovanovic, Kerry J. Ressler, Bekh Bradley

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Background: Attentional disruptions are common in PTSD, but findings across neuropsychological and neuroimaging studies have been variable. Few PTSD studies have investigated abnormalities in attention networks using a multi-modal imaging approach and attentional tasks that include emotionally-salient images. This study combined a behavioral task that included these images (emotional Stroop)with functional and structural neuroimaging (fMRI and diffusion tensor imaging; DTI)methods to comprehensively investigate attentional control abnormalities in a highly-traumatized civilian sample. Methods: 48 traumatized women with and without PTSD received clinical assessments, fMRI and DTI. During fMRI, the Affective Stroop (AS), an attentional control task that includes emotionally-salient distractor images (trauma-relevant, positive, neutral)and variable task demands, was administered. Results: In response to more difficult AS trials, participants with PTSD demonstrated lower activation in the dorsal and rostral anterior cingulate cortex and greater activation in the insula. This group also showed comparatively poorer performance on positive AS distractor trials, even after adjusting for trauma exposure. Performance on these trials inversely correlated with structural integrity of the cingulum bundle and uncinate fasciculus. Conclusions: Even after adjusting for trauma exposure, participants with PTSD showed worse performance on an attentional control task in the context of emotional stimuli. They also showed relatively lower cognitive control network activation and greater salience network activation. Fronto-parietal and fronto-limbic white matter connectivity corresponded with AS performance. Our findings indicate that attentional control impairments in PTSD are most evident in the context of emotional cues, and are related to decrements in function and structure of cognitive control and salience networks.

Original languageEnglish (US)
Pages (from-to)343-351
Number of pages9
JournalJournal of Affective Disorders
Volume253
DOIs
StatePublished - Jun 15 2019

    Fingerprint

Keywords

  • Attention
  • Cognition
  • DTI
  • PTSD
  • Stroop
  • Structure
  • fMRI

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

Cite this

Fani, N., King, T. Z., Clendinen, C., Hardy, R. A., Surapaneni, S., Blair, J. R., White, S. F., Powers, A., Ely, T. D., Jovanovic, T., Ressler, K. J., & Bradley, B. (2019). Attentional control abnormalities in posttraumatic stress disorder: Functional, behavioral, and structural correlates. Journal of Affective Disorders, 253, 343-351. https://doi.org/10.1016/j.jad.2019.04.098