Atrioventricular mechanical coupling and major adverse cardiac events in female patients following acute ST elevation myocardial infarction

Sören J. Backhaus, Johannes T. Kowallick, Thomas Stiermaier, Torben Lange, Alexander Koschalka, Jenny Lou Navarra, Johannes Uhlig, Joachim Lotz, Shelby Kutty, Boris Bigalke, Matthias Gutberlet, Gerd Hasenfuß, Holger Thiele, Ingo Eitel, Andreas Schuster

Research output: Contribution to journalArticle

Abstract

Background: Sex-specific outcome data following myocardial infarction (MI) are inconclusive with some evidence suggesting association of female sex and increased major adverse cardiac events (MACE). Since mechanistic principles remain elusive, we aimed to quantify the underlying phenotype using cardiovascular magnetic resonance (CMR) quantitative deformation imaging and tissue characterisation. Methods: In total, 795 ST-elevation MI patients underwent post-interventional CMR imaging. Feature-tracking (CMR-FT) was performed in a blinded core-laboratory. Left ventricular function was quantified using ejection fraction (LVEF) and global longitudinal/circumferential/radial strains (GLS/GCS/GRS). Left atrial function was assessed by reservoir (εs), conduit (εe) and booster-pump strains (εa). Tissue characterisation included infarct size, microvascular obstruction and area at risk. Primary endpoint was the occurrence of MACE within 1 year. Results: Female sex was associated with increased MACE (HR 1.96, 95% CI 1.13–3.42, p = 0.017) but not independently of baseline confounders (p = 0.526) with women being older, more often diabetic and hypertensive (p < 0.001) and of higher Killip-class (p = 0.010). Tissue characterisation was similar between sexes. Women showed impaired atrial (εs p = 0.011, εe p < 0.001) but increased systolic ventricular mechanics (GLS p = 0.001, LVEF p = 0.048). While atrial and ventricular function predicted MACE in men only LV GLS and GCS were associated with MACE in women irrespective of confounders (GLS p = 0.036, GCS p = 0.04). Conclusion: In men ventricular systolic contractility is impaired and volume assessments precisely stratify elevated risks. In contrast, women experience reduced atrial but increased ventricular systolic strain. This may reflect ventricular diastolic failure with systolic compensation, which is independently associated with MACE adding incremental value to sex-specific prognosis evaluation.

Original languageEnglish (US)
Pages (from-to)31-36
Number of pages6
JournalInternational Journal of Cardiology
Volume299
DOIs
StatePublished - Jan 15 2020

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Interventional Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Atrial Function
Left Atrial Function
Ventricular Function
Mechanics
Left Ventricular Function
Myocardial Infarction
ST Elevation Myocardial Infarction
Phenotype

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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Atrioventricular mechanical coupling and major adverse cardiac events in female patients following acute ST elevation myocardial infarction. / Backhaus, Sören J.; Kowallick, Johannes T.; Stiermaier, Thomas; Lange, Torben; Koschalka, Alexander; Navarra, Jenny Lou; Uhlig, Johannes; Lotz, Joachim; Kutty, Shelby; Bigalke, Boris; Gutberlet, Matthias; Hasenfuß, Gerd; Thiele, Holger; Eitel, Ingo; Schuster, Andreas.

In: International Journal of Cardiology, Vol. 299, 15.01.2020, p. 31-36.

Research output: Contribution to journalArticle

Backhaus, SJ, Kowallick, JT, Stiermaier, T, Lange, T, Koschalka, A, Navarra, JL, Uhlig, J, Lotz, J, Kutty, S, Bigalke, B, Gutberlet, M, Hasenfuß, G, Thiele, H, Eitel, I & Schuster, A 2020, 'Atrioventricular mechanical coupling and major adverse cardiac events in female patients following acute ST elevation myocardial infarction', International Journal of Cardiology, vol. 299, pp. 31-36. https://doi.org/10.1016/j.ijcard.2019.06.036
Backhaus, Sören J. ; Kowallick, Johannes T. ; Stiermaier, Thomas ; Lange, Torben ; Koschalka, Alexander ; Navarra, Jenny Lou ; Uhlig, Johannes ; Lotz, Joachim ; Kutty, Shelby ; Bigalke, Boris ; Gutberlet, Matthias ; Hasenfuß, Gerd ; Thiele, Holger ; Eitel, Ingo ; Schuster, Andreas. / Atrioventricular mechanical coupling and major adverse cardiac events in female patients following acute ST elevation myocardial infarction. In: International Journal of Cardiology. 2020 ; Vol. 299. pp. 31-36.
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T1 - Atrioventricular mechanical coupling and major adverse cardiac events in female patients following acute ST elevation myocardial infarction

AU - Backhaus, Sören J.

AU - Kowallick, Johannes T.

AU - Stiermaier, Thomas

AU - Lange, Torben

AU - Koschalka, Alexander

AU - Navarra, Jenny Lou

AU - Uhlig, Johannes

AU - Lotz, Joachim

AU - Kutty, Shelby

AU - Bigalke, Boris

AU - Gutberlet, Matthias

AU - Hasenfuß, Gerd

AU - Thiele, Holger

AU - Eitel, Ingo

AU - Schuster, Andreas

PY - 2020/1/15

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N2 - Background: Sex-specific outcome data following myocardial infarction (MI) are inconclusive with some evidence suggesting association of female sex and increased major adverse cardiac events (MACE). Since mechanistic principles remain elusive, we aimed to quantify the underlying phenotype using cardiovascular magnetic resonance (CMR) quantitative deformation imaging and tissue characterisation. Methods: In total, 795 ST-elevation MI patients underwent post-interventional CMR imaging. Feature-tracking (CMR-FT) was performed in a blinded core-laboratory. Left ventricular function was quantified using ejection fraction (LVEF) and global longitudinal/circumferential/radial strains (GLS/GCS/GRS). Left atrial function was assessed by reservoir (εs), conduit (εe) and booster-pump strains (εa). Tissue characterisation included infarct size, microvascular obstruction and area at risk. Primary endpoint was the occurrence of MACE within 1 year. Results: Female sex was associated with increased MACE (HR 1.96, 95% CI 1.13–3.42, p = 0.017) but not independently of baseline confounders (p = 0.526) with women being older, more often diabetic and hypertensive (p < 0.001) and of higher Killip-class (p = 0.010). Tissue characterisation was similar between sexes. Women showed impaired atrial (εs p = 0.011, εe p < 0.001) but increased systolic ventricular mechanics (GLS p = 0.001, LVEF p = 0.048). While atrial and ventricular function predicted MACE in men only LV GLS and GCS were associated with MACE in women irrespective of confounders (GLS p = 0.036, GCS p = 0.04). Conclusion: In men ventricular systolic contractility is impaired and volume assessments precisely stratify elevated risks. In contrast, women experience reduced atrial but increased ventricular systolic strain. This may reflect ventricular diastolic failure with systolic compensation, which is independently associated with MACE adding incremental value to sex-specific prognosis evaluation.

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