Atrial natriuretic factor inhibits angiotensin-induced aldosterone secretion: Not through cGMP or interference with phospholipase C

Arunabha Ganguly, Shirley Chiou, Leigh A. West, John S. Davis

Research output: Contribution to journalArticle

29 Scopus citations


ANF did not prevent the formation of [3H] inositol trisphosphate in response to All but inhibited aldosterone secretion in calf adrenal glomerulosa cells. 8-bromo cGMP did not affect either inositol phosphate formation or aldosterone secretion. Changes in cytosolic Ca++ concentration induced by All, as measured by Quin 2 fluorescence, were also unaffected by ANF. No difference in adrenal cell protein phosphorylation with All or All+ANF was observed. The results suggest that ANF may inhibit aldosterone secretion through a non-guanyl cyclase linked receptor system not involving the formation of phosphoinositide-derived second messengers. Interference with protein kinase C activity cannot be ruled out.

Original languageEnglish (US)
Pages (from-to)148-154
Number of pages7
JournalBiochemical and Biophysical Research Communications
Issue number1
Publication statusPublished - Feb 28 1989


ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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